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Fecal Calprotectin: A Reliable Predictor of Mucosal Healing after Treatment for Active Ulcerative Colitis
Joint Authors
Kristensen, Vendel
Røseth, Arne
Ahmad, Tahir
Skar, Viggo
Moum, Bjørn
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
Mucosal healing has become the new goal of treatment in ulcerative colitis.
Fecal calprotectin has been demonstrated to differentiate between mucosal inflammation and mucosal healing.
With this project, we investigated whether a reduction in f-calprotectin to <250 μg/g after medical treatment for active ulcerative colitis could predict mucosal healing.
Material and Methods.
After a baseline colonoscopy, 20 patients with active ulcerative colitis were followed with consecutive fecal calprotectin monthly until two measurements of fecal calprotectin < 250 μg/g or a maximum follow-up of 12 months.
A flexible sigmoidoscopy was then performed and Mayo endoscopic subscore was used to evaluate degree of inflammation.
Simple Clinical Colitis Activity Index was used for evaluation of clinical disease activity.
Results.
A total of 16 patients achieved fecal calprotectin < 250 μg/g during follow-up, and all 16 patients had endoscopic mucosal healing (Mayo endoscopic subscore of ≤1) on the second endoscopy.
The remaining four patients had persistently high f-calprotectin levels before the second endoscopy with Mayo endoscopic subscore corresponding to endoscopic mucosal healing in three out of four patients.
Conclusions.
Fecal calprotectin <250 μg/g after medical treatment for active ulcerative colitis is a reliable marker of endoscopic mucosal healing.
American Psychological Association (APA)
Kristensen, Vendel& Røseth, Arne& Ahmad, Tahir& Skar, Viggo& Moum, Bjørn. 2017. Fecal Calprotectin: A Reliable Predictor of Mucosal Healing after Treatment for Active Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156233
Modern Language Association (MLA)
Kristensen, Vendel…[et al.]. Fecal Calprotectin: A Reliable Predictor of Mucosal Healing after Treatment for Active Ulcerative Colitis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1156233
American Medical Association (AMA)
Kristensen, Vendel& Røseth, Arne& Ahmad, Tahir& Skar, Viggo& Moum, Bjørn. Fecal Calprotectin: A Reliable Predictor of Mucosal Healing after Treatment for Active Ulcerative Colitis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156233