Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300)
Joint Authors
Tang, Li
Fang, Jing
Ou, Yangping
Geng, Yi
Huang, Xiaoli
Wang, Kaiyu
Chen, Defang
Yin, Lizi
Ruixue, Yang
Jiaqiang, Deng
Weimin, Lai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Staphylococcus aureus (S.
aureus), an important opportunistic pathogen in human and animal, causes a series of diseases in the impairing of immunity of host and even then death.
Alpha-hemolysin (Hla), a primary virulence factor, plays a major role in the pathogenic progress of S.
aureus, especially in pneumonia.
Prim-O-glucosylcimifugin (POG), a nature chromone compound, is an active ingredient in many Chinese Medicines.
In this study, POG investigated the inhibitory effect of the secretion of Hla in S.
aureus strain USA300 at the subinhibitory concentrations.
The hemolysis assays and western blotting assays showed that POG can decrease the production of Hla in the USA300 growth cell cultures in a dose-dependent manner.
The results of RT-PCR revealed that reduction of Hla was related to inhibit the transcription of hla and RNAIII.
In the cells experiment, POG was proved to protect A549 cells from Hla-medicated injury.
In conclusion, POG was shown the capacity of decreased the production of S.
aureus Hla.
POG can be developed as a candidate agent to treat S.
aureus infections against Hla.
American Psychological Association (APA)
Ou, Yangping& Ruixue, Yang& Jiaqiang, Deng& Wang, Kaiyu& Fang, Jing& Geng, Yi…[et al.]. 2018. Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156240
Modern Language Association (MLA)
Ou, Yangping…[et al.]. Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156240
American Medical Association (AMA)
Ou, Yangping& Ruixue, Yang& Jiaqiang, Deng& Wang, Kaiyu& Fang, Jing& Geng, Yi…[et al.]. Subinhibitory Concentrations of Prim-O-Glucosylcimifugin Decrease the Expression of Alpha-Hemolysin in Staphylococcus aureus (USA300). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156240