Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
Joint Authors
Zhang, Hongying
Dong, Jingcheng
Mohammadtursun, Nabijan
Wang, Genfa
Lv, Yu-bao
Sun, Jing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic.
Current approaches are disappointing due to limited improvement of the disease development.
The present study established 36-week side stream cigarette smoke induced rat model of COPD with advanced stage feature and evaluted the effects of baicalin on the model.
Fifty-four Sprague–Dawley rats were randomly divided into six groups including room air control, cigarette smoke exposure, baicalin (40 mg/kg, 80 mg/kg, and 160 mg/kg), and budesonide used as a positive control.
Rats were exposed to cigarette smoke from 3R4F research cigarettes.
Pulmonary function was evaluated and pathological changes were also observed.
Cytokine level related to airway inflammation and remodelling in blood serum, bronchoalveolar lavage fluid, and lung tissue was determined.
Blood gases and HPA axis function were also examined, and antioxidant levels were quantified.
Results showed that, after treatment with baicalin, lung function was improved and histopathological changes were ameliorated.
Baicalin also regulated proinflammatory and anti-inflammatory balance and also airway remodelling and anti-airway remodelling factors in blood serum, bronchoalveolar lavage fluid, and lung tissue.
Antioxidant capacity was also increased after treatment with baicalin in COPD rat model.
HPA axis function was improved in baicalin treated groups as compared to model group.
Therefore, baicalin exerts lung function protection, proinflammatory and anti-inflammatory cytokine regulation, anti-airway remodelling, and antioxidant role in long term CS induced COPD model.
American Psychological Association (APA)
Wang, Genfa& Mohammadtursun, Nabijan& Lv, Yu-bao& Zhang, Hongying& Sun, Jing& Dong, Jingcheng. 2018. Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156242
Modern Language Association (MLA)
Wang, Genfa…[et al.]. Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156242
American Medical Association (AMA)
Wang, Genfa& Mohammadtursun, Nabijan& Lv, Yu-bao& Zhang, Hongying& Sun, Jing& Dong, Jingcheng. Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156242