Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast
Joint Authors
Ballesteros-Ramírez, Ricardo
Aldana, Eliana
Herrera, María Victoria
Urueña, Claudia
Rojas, Laura Yinneth
Echeverri, Luis Fernando
Costa, Geison Modesti
Quijano, Sandra
Fiorentino, Susana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The need for new therapeutic approaches to improve the response in acute leukemia (AL), either by directing therapy or with new therapeutic alternatives, has been a research and clinical interest topic.
We evaluated whether blasts from AL patients were sensitive ex vivo to the induction chemotherapy and whether the extracts of Petiveria alliacea (Anamu SC) and Caesalpinia spinosa (P2Et) modulated the sensitivity of leukemic cells to death.
Bone marrow samples were taken from 26 patients with de novo AL and 6 in relapse, and the cytotoxicity of the extracts alone or in combination with the chemotherapeutic was evaluated by XTT.
Patients were classified as good (GR) and bad responders (BR) according to the ex vivo test.
70.5% of the GR patients to the ex vivo test achieved postinduction remission to induction chemotherapy with a median overall survival of 12.50 months versus 7.23 months in the two groups.
Furthermore, it was found that the ex vivo response to extracts and chemotherapeutics is heterogeneous and shows an exclusive pattern between the extracts, Anamu being the more effective in inducing cell death.
The combination of extracts with chemotherapeutic agents showed synergistic or antagonistic effects in the patients’ blasts.
These results show that the ex vivo evaluation of the sensitivity to induction drugs using primary blasts from patients exhibits a correlation with the response to induction chemotherapy in patients.
These analyses would allow establishing a system to predict response to treatment and determine ex vivo susceptibility to new therapies under development, among which is phytotherapeutics.
American Psychological Association (APA)
Ballesteros-Ramírez, Ricardo& Aldana, Eliana& Herrera, María Victoria& Urueña, Claudia& Rojas, Laura Yinneth& Echeverri, Luis Fernando…[et al.]. 2020. Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1156251
Modern Language Association (MLA)
Ballesteros-Ramírez, Ricardo…[et al.]. Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1156251
American Medical Association (AMA)
Ballesteros-Ramírez, Ricardo& Aldana, Eliana& Herrera, María Victoria& Urueña, Claudia& Rojas, Laura Yinneth& Echeverri, Luis Fernando…[et al.]. Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1156251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156251