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Enriched-Baicalein Attenuates Allergy in Cells and Mice
Joint Authors
Yun, Mi-Young
Jung, Ju-Im
Park, Sung-Min
Choi, Hwa-Jung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Enriched-baicalein (baicalein) from baicalin was prepared by fermentation of an SB extract with mycelium of Laetiporus sulphureus.
To investigate the pharmacologic effects of baicalein, its antiallergic effect was measured in vitro and in vivo.
Allergy was induced by intraperitoneal injection of ovalbumin (OVA) into Balb/c mice.
As a result, baicalein showed antiallergic effects by inhibiting the release of β-hexosaminidase from immunoglobulin E- (IgE-) stimulated rat basophilic leukemia (RBL-2H3) mast cells without cytotoxicity after the methodology.
After four weeks, the decrease of OVA-specific IgE level, decrease of histamine and tryptase level in serum, and then the decrease of the levels of T helper type 2 (Th2) cell-derived cytokines interleukin- (IL-) 4 and IL-13 in the splenocyte were observed.
In a histological analysis for lung, baicalein excellently reduced eosinophil infiltration with the inhibition of characteristic lesions and inflammation including OVA-induced necrosis, numbers of inflammatory cells, and pulmonary edema.
Therefore, these results showed that baicalein had excellent efficacy in the antiallergic activity.
American Psychological Association (APA)
Yun, Mi-Young& Jung, Ju-Im& Park, Sung-Min& Choi, Hwa-Jung. 2020. Enriched-Baicalein Attenuates Allergy in Cells and Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156261
Modern Language Association (MLA)
Yun, Mi-Young…[et al.]. Enriched-Baicalein Attenuates Allergy in Cells and Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156261
American Medical Association (AMA)
Yun, Mi-Young& Jung, Ju-Im& Park, Sung-Min& Choi, Hwa-Jung. Enriched-Baicalein Attenuates Allergy in Cells and Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156261