![](/images/graphics-bg.png)
Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis
Joint Authors
Reszec, Joanna
Lebensztejn, Dariusz Marek
Lotowska, Joanna Maria
Sobaniec-Lotowska, Maria Elzbieta
Daniluk, Urszula
Sobaniec, Piotr
Sendrowski, Krzysztof
Daniluk, Jaroslaw
Debek, Wojciech
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Recently, it has been emphasized that hepatic progenitor/oval cells (HPCs) are significantly involved in liver fibrogenesis.
We evaluated the multipotential population of HPCs by transmission electron microscope (TEM), including relations with adherent hepatic nonparenchymal cells (NPCs) in rats with biliary fibrosis induced by bile duct ligation (BDL).
Methods.
The study used 6-week-old Wistar Crl: WI(Han) rats after BDL for 1, 6, and 8 weeks.
Results.
Current ultrastructural analysis showed considerable proliferation of HPCs in experimental intensive biliary fibrosis.
HPCs formed proliferating bile ductules and were scattered in periportal connective tissue.
We distinguished 4 main types of HPCs: 0, I, II (bile duct-like cells; most common), and III (hepatocyte-like cells).
We observed, very seldom presented in literature, cellular interactions between HPCs and adjacent NPCs, especially commonly found transitional hepatic stellate cells (T-HSCs) and Kupffer cells/macrophages.
We showed the phenomenon of penetration of the basement membrane of proliferating bile ductules by cytoplasmic processes sent by T-HSCs and the formation of direct cell-cell contact with ductular epithelial cells related to HPCs.
Conclusions.
HPC proliferation induced by BDL evidently promotes portal fibrogenesis.
Better understanding of the complex cellular interactions between HPCs and adjacent NPCs, especially T-HSCs, may help develop antifibrotic therapies in the future.
American Psychological Association (APA)
Lotowska, Joanna Maria& Sobaniec-Lotowska, Maria Elzbieta& Lebensztejn, Dariusz Marek& Daniluk, Urszula& Sobaniec, Piotr& Sendrowski, Krzysztof…[et al.]. 2017. Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156273
Modern Language Association (MLA)
Lotowska, Joanna Maria…[et al.]. Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156273
American Medical Association (AMA)
Lotowska, Joanna Maria& Sobaniec-Lotowska, Maria Elzbieta& Lebensztejn, Dariusz Marek& Daniluk, Urszula& Sobaniec, Piotr& Sendrowski, Krzysztof…[et al.]. Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156273