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Bowel Ischemia in ICU Patients: Diagnostic Value of I-FABP Depends on the Interval to the Triggering Event
Joint Authors
Zanow, Jürgen
Rauchfuß, Falk
Ludewig, Stefan
Jarbouh, Rami
Ardelt, Michael
Mothes, Henning
Fahrner, René
Settmacher, Utz
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Intestinal fatty acid-binding protein (I-FABP) has been shown to be of high diagnostic value in patients with acute mesenteric ischemia.
Whether these results can be reproduced in critically ill patients on the ICU was to be investigated.
Materials and Methods.
I-FABP was measured in serum and urine of 43 critically ill patients in ICU when mesenteric ischemia was suspected.
Bowel ischemia was confirmed in 21 patients (group 1).
22 patients who survived at least seven days without confirmation of ischemia were assigned to group 2.
I-FABP levels were compared between the groups, and interval from the event that has triggered ischemia to I-FABP measurement was recorded.
Results.
For the identification of patients with mesenteric ischemia, sensitivity, specificity, and area under the curve (AUC) for serum and urine I-FABP were 33.3%, 95.5%, and 0.565 and 81.3%, 70.0%, and 0.694, respectively.
I-FABP measurements performed within 12 to 48 h after the event that triggered ischemia showed a sensitivity, specificity, and AUC for serum and urine of 75%, 100%, and 0.853 and 100%, 73.3%, and 0.856, respectively.
Conclusions.
In ICU patients, one single I-FABP measurement at the time of clinical suspicion failed to reliably detect or exclude mesenteric ischemia.
A higher diagnostic value of I-FABP was only confirmed in the early stages of mesenteric ischemia.
I-FABP may be used most appropriately in perioperative monitoring.
American Psychological Association (APA)
Ludewig, Stefan& Jarbouh, Rami& Ardelt, Michael& Mothes, Henning& Rauchfuß, Falk& Fahrner, René…[et al.]. 2017. Bowel Ischemia in ICU Patients: Diagnostic Value of I-FABP Depends on the Interval to the Triggering Event. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156283
Modern Language Association (MLA)
Ludewig, Stefan…[et al.]. Bowel Ischemia in ICU Patients: Diagnostic Value of I-FABP Depends on the Interval to the Triggering Event. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156283
American Medical Association (AMA)
Ludewig, Stefan& Jarbouh, Rami& Ardelt, Michael& Mothes, Henning& Rauchfuß, Falk& Fahrner, René…[et al.]. Bowel Ischemia in ICU Patients: Diagnostic Value of I-FABP Depends on the Interval to the Triggering Event. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156283