Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis

Joint Authors

McClain, Craig J.
Feng, Wenke
Liu, Liming
Zhao, Cuiqing
Yang, Ying
Kong, Xiaoxia
Shao, Tuo
Ren, Li
Zhuang, Xinyu
Yin, Baishuang
Dryden, Gerald
Luan, Weimin

Source

Gastroenterology Research and Practice

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-05-11

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

Aims.

Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD).

Adipose tissue plays a critical role in regulating energy balance.

Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis.

We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis.

Methods.

Mice were given 2.5% dextran sulfate sodium (DSS) ad libitum for 7 days to induce colitis.

The role of FGF21 was investigated using antibody neutralization or knockout (KO) mice.

Lipolysis index and adipose lipolytic enzymes were determined.

In addition, 3T3-L1 cells were pretreated with IL-6, followed by recombinant human FGF21 (rhFGF21) treatment; lipolysis was assessed.

Results.

DSS markedly decreased eWAT/body weight ratio and increased serum concentrations of free fatty acid (FFA) and glycerol, indicating increased adipose tissue lipolysis.

eWAT intracellular lipolytic enzyme expression/activation was significantly increased.

These alterations were significantly attenuated in FGF21 KO mice and by circulating FGF21 neutralization.

Moreover, DSS treatment markedly increased serum IL-6 and FGF21 levels.

IL-6 pretreatment was necessary for the stimulatory effect of FGF21 on adipose lipolysis in 3T3-L1 cells.

Conclusions.

Our results demonstrate that experimental colitis induces eWAT lipolysis via an IL-6/FGF21-mediated signaling pathway.

American Psychological Association (APA)

Liu, Liming& Zhao, Cuiqing& Yang, Ying& Kong, Xiaoxia& Shao, Tuo& Ren, Li…[et al.]. 2017. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156302

Modern Language Association (MLA)

Liu, Liming…[et al.]. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156302

American Medical Association (AMA)

Liu, Liming& Zhao, Cuiqing& Yang, Ying& Kong, Xiaoxia& Shao, Tuo& Ren, Li…[et al.]. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156302

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1156302