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Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis
Joint Authors
McClain, Craig J.
Feng, Wenke
Liu, Liming
Zhao, Cuiqing
Yang, Ying
Kong, Xiaoxia
Shao, Tuo
Ren, Li
Zhuang, Xinyu
Yin, Baishuang
Dryden, Gerald
Luan, Weimin
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD).
Adipose tissue plays a critical role in regulating energy balance.
Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis.
We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis.
Methods.
Mice were given 2.5% dextran sulfate sodium (DSS) ad libitum for 7 days to induce colitis.
The role of FGF21 was investigated using antibody neutralization or knockout (KO) mice.
Lipolysis index and adipose lipolytic enzymes were determined.
In addition, 3T3-L1 cells were pretreated with IL-6, followed by recombinant human FGF21 (rhFGF21) treatment; lipolysis was assessed.
Results.
DSS markedly decreased eWAT/body weight ratio and increased serum concentrations of free fatty acid (FFA) and glycerol, indicating increased adipose tissue lipolysis.
eWAT intracellular lipolytic enzyme expression/activation was significantly increased.
These alterations were significantly attenuated in FGF21 KO mice and by circulating FGF21 neutralization.
Moreover, DSS treatment markedly increased serum IL-6 and FGF21 levels.
IL-6 pretreatment was necessary for the stimulatory effect of FGF21 on adipose lipolysis in 3T3-L1 cells.
Conclusions.
Our results demonstrate that experimental colitis induces eWAT lipolysis via an IL-6/FGF21-mediated signaling pathway.
American Psychological Association (APA)
Liu, Liming& Zhao, Cuiqing& Yang, Ying& Kong, Xiaoxia& Shao, Tuo& Ren, Li…[et al.]. 2017. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156302
Modern Language Association (MLA)
Liu, Liming…[et al.]. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156302
American Medical Association (AMA)
Liu, Liming& Zhao, Cuiqing& Yang, Ying& Kong, Xiaoxia& Shao, Tuo& Ren, Li…[et al.]. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156302