Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation
Joint Authors
Ypsilantis, Petros
Evagellou, Antonios
Papadopoulos, Nikolaos
Simopoulos, Konstantinos
Lambropoulou, Maria
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aim.
Extended liver radiofrequency ablation (RFA) has been shown to disrupt gut barrier integrity with subsequent bacterial translocation.
The aim of the present project was to study the immune and inflammatory responses of the intestinal mucosa after extended RFA of the liver.
Methods.
Twelve Wistar rats were either subjected to RFA of the left lateral hepatic lobe (approximately 30% of the liver mass) after midline laparotomy (group RFA, n=6) or sham operation (group Sham, n=6).
Forty-eight hours later, ileal tissue specimens were excised for immunohistochemical assessment of CD68+ macrophages, CD4+ T-lymphocytes, CD8+ T-lymphocytes, mucosal addressin cell adhesion molecule-1 (MAdCAM-1), tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), and nuclear factor-κB (NFκB) expression.
Results.
Immune response biomarkers were upregulated in the RFA group.
Expression of CD4+ and CD8+ T-lymphocytes was moderate, while that of CD68+ macrophages and MAdCAM-1 was high.
Inflammatory response biomarkers were also upregulated in the RFA group.
TNFα, IL-6, and NFκB expression was low, moderate, and high, respectively.
Conclusions.
Extended liver RFA evokes both immune and inflammatory responses of the gut mucosa.
American Psychological Association (APA)
Ypsilantis, Petros& Lambropoulou, Maria& Evagellou, Antonios& Papadopoulos, Nikolaos& Simopoulos, Konstantinos. 2017. Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156313
Modern Language Association (MLA)
Ypsilantis, Petros…[et al.]. Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156313
American Medical Association (AMA)
Ypsilantis, Petros& Lambropoulou, Maria& Evagellou, Antonios& Papadopoulos, Nikolaos& Simopoulos, Konstantinos. Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156313