Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALBc Mice
Joint Authors
Chiranthanut, Natthakarn
Panthong, Ampai
Khonsung, Parirat
Na Takuathung, Mingkwan
Wongnoppavich, Ariyaphong
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by thick and erythema raised plaques with adherent silvery scales.
T-cells are activated via the IL-23/Th17 axis which is involved in psoriasis pathogenesis.
Conventional treatments of psoriasis have adverse events that influence patients’ adherence.
Wannachawee Recipe (WCR) is Thai traditional medicine that is known to be effective for psoriasis patients; however, preclinical evidence is still lacking.
This study investigated the therapeutic potential of WCR on antiproliferant activity using imiquimod- (IMQ-) induced psoriasis-like dermatitis in a mouse model.
Psoriasis-like dermatitis was induced on the shaved dorsal skin and right ear pinna of BALB/c mice by topical application of IMQ for 15 consecutive days after which WCR was administered to the mice by oral gavage for 10 days.
Phenotypical observations, histopathological examinations, and ELISA of skin and blood samples were conducted.
WCR significantly ameliorated development of IMQ-induced psoriasis-like dermatitis and reduced levels of Th17 cytokines (IL-17A, IL-22, and IL-23) in both serum and dorsal skin.
Histopathological findings showed a decrease in epidermal thickness and inflammatory T-cell infiltration in the WCR-treated groups.
The WCR has pharmacological actions which regulate Th17 related cytokines suggesting that it is a potential alternative therapeutic strategy for psoriasis.
American Psychological Association (APA)
Na Takuathung, Mingkwan& Wongnoppavich, Ariyaphong& Panthong, Ampai& Khonsung, Parirat& Chiranthanut, Natthakarn& Soonthornchareonnon, Noppamas…[et al.]. 2018. Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156322
Modern Language Association (MLA)
Na Takuathung, Mingkwan…[et al.]. Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156322
American Medical Association (AMA)
Na Takuathung, Mingkwan& Wongnoppavich, Ariyaphong& Panthong, Ampai& Khonsung, Parirat& Chiranthanut, Natthakarn& Soonthornchareonnon, Noppamas…[et al.]. Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156322