Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?
Joint Authors
Clavo, Bernardino
Llontop, Pedro
Rovira, Gloria
Suarez, Gerardo
Santana-Rodríguez, Norberto
Gutiérrez, Dominga
López, Laura
González, Esteban
Jorge, Ignacio J.
Perera, Carmen
Blanco, Jesús
Rodríguez-Esparragón, Francisco
Martínez-Sánchez, Gregorio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
This article provides an overview of the potential use of ozone as an adjuvant during cancer treatment.
Methods.
We summarize the findings of the most relevant publications focused on this goal, and we include our related clinical experience.
Results.
Over several decades, prestigious journals have published in vitro studies on the capacity of ozone to induce direct damage on tumor cells and, as well, to enhance the effects of radiotherapy and chemotherapy.
Indirect effects have been demonstrated in animal models: immune modulation by ozone alone and sensitizing effect of radiotherapy by concurrent ozone administration.
The effects of ozone in modifying hemoglobin dissociation curve, 2,3-diphosphoglycerate levels, locoregional blood flow, and tumor hypoxia provide additional support for potential beneficial effects during cancer treatment.
Unfortunately, only a few clinical studies are available.
Finally, we describe some works and our experience supporting the potential role of local ozone therapy in treating delayed healing after tumor resection, to avoid delays in commencing radiotherapy and chemotherapy.
Conclusions.
In vitro and animal studies, as well as isolated clinical reports, suggest the potential role of ozone as an adjuvant during radiotherapy and/or chemotherapy.
However, further research, such as randomized clinical trials, is required to demonstrate its potential usefulness as an adjuvant therapeutic tool.
American Psychological Association (APA)
Clavo, Bernardino& Santana-Rodríguez, Norberto& Llontop, Pedro& Gutiérrez, Dominga& Suarez, Gerardo& López, Laura…[et al.]. 2018. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156327
Modern Language Association (MLA)
Clavo, Bernardino…[et al.]. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156327
American Medical Association (AMA)
Clavo, Bernardino& Santana-Rodríguez, Norberto& Llontop, Pedro& Gutiérrez, Dominga& Suarez, Gerardo& López, Laura…[et al.]. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156327