Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn’s Disease

Abstract EN

The aim of this study is to investigate the diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with Crohn’s disease (CD) and non-CD controls.

These ratios were all derived from complete blood counts.

Two hundred and six participants including CD inpatients and non-CD controls were retrospectively enrolled.

We found statistically higher NLR and PLR and lower LMR in CD patients than in non-CD controls (all P<0.01).

However, NMR was not different between the two groups (P=0.18).

In addition, NLR, PLR, and LMR were associated with CRP and ESR.

Optimal cutoffs for NLR and PLR were 2.72 (sensitivity: 68.3%, specificity: 75.9%, and overall accuracy: 70.1%) and 132.88 (sensitivity: 76.7%, specificity: 84.8%, and overall accuracy: 80.8%), respectively.

In conclusion, the NLR and PLR might be effective, readily available, and low-cost biomarkers for differentiating CD patients from non-CD controls.