Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice
Joint Authors
Lin, Yi-Wen
Liao, Hsien-Yin
Huang, Hung-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Comorbidity of chronic pain and major depression disorder (MDD) are common diseases.
However, the mechanisms of electroacupuncture (EA) and the responses of N-methyl-D-aspartate receptors in the brain remain unclear.
Three injections of complete Freund's adjuvant (CFA) were administered to induce chronic inflammatory pain (CIP).
EA was then performed once every other day from days 14 to 28.
Behavior tests of chronic pain and depression were evaluated to make sure of the successful induction of comorbidity.
We used Western blotting to analyze brain tissue from the prefrontal cortex (PFC), hippocampus, and hypothalamus for levels of phosphorylated N-methyl-D-aspartate receptor subunit 1 (pNR1), NR1, pNR2B, NR2B, and calcium/calmodulin-dependent protein kinase type II alpha isoform (pCaMKIIα).
The mechanical hyperalgesia, thermal hyperalgesia, and depression were observed in the CIP group.
Furthermore, decreased levels of N-methyl-D-aspartate receptors (NMDARs) were also noted.
Not Sham EA but EA reversed chronic pain and depression as well as the decreased levels of NMDA in the signaling pathway.
The CFA injections successfully induced a significant comorbidity model.
EA treated the comorbidity by upregulating the NMDA signaling pathway in the PFC, hippocampus, and hypothalamus.
Our results indicated significant mechanisms of comorbidity of chronic pain and MDD and EA-analgesia that involves the regulation of the NMDAR signaling pathway.
These findings may be relevant to the evaluation and treatment of comorbidity of chronic pain and MDD.
American Psychological Association (APA)
Huang, Hung-Yu& Liao, Hsien-Yin& Lin, Yi-Wen. 2020. Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156336
Modern Language Association (MLA)
Huang, Hung-Yu…[et al.]. Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156336
American Medical Association (AMA)
Huang, Hung-Yu& Liao, Hsien-Yin& Lin, Yi-Wen. Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156336