Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats
Joint Authors
Pan, Yan
Yao, Qing
Lu, Xiaohong
Zhang, Qian
Luo, Mingxiu
Li, P. Andy
Yang, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic retinopathy (DR) has become the most frequent cause of impaired visual acuity and blindness in working-age population in developed countries.
Here we use diabetic rats to clarify the role of Lycium barbarum polysaccharides (LBP) on DR.
We treated diabetic rats with LBP (400 mg/kg/d or 200 mg/kg/d) orally for 20 weeks.
Electroretinogram (ERGs) and Laser Doppler blood flow were measured to assess the retinal function, routine histology and ultrastructural studies were performed to evaluate the morphological alterations, and immunohistochemistry, western blotting, and RT-PCR were conducted to detect the protein and mRNA levels of pro- and antiangiogenic factors.
The results showed that diabetes suppressed the amplitudes of a-wave, b-wave, and oscillatory potential in ERG, reduced retinal blood flow, decreased the thickness of the retina, and increased the thickness of basement membrane of the retinal capillary.
Furthermore, diabetes increased the mRNA and protein expressions of proangiogenic GFAP and VEGF and suppressed the levels of antiangiogenic PEDG.
Treatment with LBP either completely or partially reversed the alterations caused by diabetes.
It is concluded that the LBP protects retinal function and morphology in diabetic rats, probably through reinstallation of the balance between proangiogenic and antiangiogenic factors, which reduces neovascularization.
LBP could be used as a therapeutic drug for DR.
American Psychological Association (APA)
Yao, Qing& Yang, Yi& Lu, Xiaohong& Zhang, Qian& Luo, Mingxiu& Li, P. Andy…[et al.]. 2018. Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156349
Modern Language Association (MLA)
Yao, Qing…[et al.]. Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156349
American Medical Association (AMA)
Yao, Qing& Yang, Yi& Lu, Xiaohong& Zhang, Qian& Luo, Mingxiu& Li, P. Andy…[et al.]. Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156349