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Modulation of Colorectal Cancer Risk by Polymorphisms in 51GlnHis, 64IleVal, and 148AspGlu of APEX Gene; 23GlyAla of XPA Gene; and 689SerArg of ERCC4 Gene
Joint Authors
Majsterek, Ireneusz
Kabzinski, J.
Dziki, A.
Dziki, L.
Mik, M.
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Polymorphisms in DNA repair genes may affect the activity of the BER (base excision repair) and NER (nucleotide excision repair) systems.
Using DNA isolated from blood taken from patients (n=312) and a control group (n=320) with CRC, we have analyzed the polymorphisms of selected DNA repair genes and we have demonstrated that genotypes 51Gln/His and 148Asp/Glu of APEX gene and 23Gly/Ala of XPA gene may increase the risk of colorectal cancer.
At the same time analyzing the gene-gene interactions, we suggest the thesis that the main factor to be considered when analyzing the impact of polymorphisms on the risk of malignant transformation should be intergenic interactions.
Moreover, we are suggesting that some polymorphisms may have impact not only on the malignant transformation but also on the stage of the tumor.
American Psychological Association (APA)
Dziki, L.& Dziki, A.& Mik, M.& Majsterek, Ireneusz& Kabzinski, J.. 2017. Modulation of Colorectal Cancer Risk by Polymorphisms in 51GlnHis, 64IleVal, and 148AspGlu of APEX Gene; 23GlyAla of XPA Gene; and 689SerArg of ERCC4 Gene. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156350
Modern Language Association (MLA)
Dziki, L.…[et al.]. Modulation of Colorectal Cancer Risk by Polymorphisms in 51GlnHis, 64IleVal, and 148AspGlu of APEX Gene; 23GlyAla of XPA Gene; and 689SerArg of ERCC4 Gene. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156350
American Medical Association (AMA)
Dziki, L.& Dziki, A.& Mik, M.& Majsterek, Ireneusz& Kabzinski, J.. Modulation of Colorectal Cancer Risk by Polymorphisms in 51GlnHis, 64IleVal, and 148AspGlu of APEX Gene; 23GlyAla of XPA Gene; and 689SerArg of ERCC4 Gene. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156350