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Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats
Joint Authors
Saputri, Fadlina Chany
Nurfaradilla, Shinta Ayu
Harahap, Yahdiana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hibiscus sabdariffa L.
(Malvaceae) is a traditional medicinal herb widely consumed as a beverage (“hibiscus tea”), and its global popularity is expanding due to health benefits such as blood pressure and cholesterol control.
Previous studies showed that Hibiscus sabdariffa is coadministered with antihypertensives and antihyperlipidemics, thus predisposing herb-drug interactions.
We investigated the pharmacokinetic interaction between H.
sabdariffa L.
aqueous extract and captopril, a frequently prescribed antihypertensive.
In this study, chemical profile of H.
sabdariffa L.
aqueous extract was identified using HPLC system equipped with a DAD detector at 360 nm and 520 nm.
The male Sprague Dawley rats were divided into two groups of six rats.
Group I received a single dose of captopril suspension (4.5 mg/200 g body weight (BW) orally (p.o.)) while group II received H.
sabdariffa L.
aqueous extract (60 mg/200 g BW; p.o.) daily for two weeks prior to the same captopril dose.
Multiple blood samples were collected at predetermined times after captopril administration and the plasma concentration was analyzed using ultrahigh-pressure liquid chromatography-tandem mass spectrometry.
Chemical profiling of the H.
sabdariffa L.
aqueous extract showed that the extract contains chlorogenic acid, myricetin 3-arabinogalactoside, 5-O-caffeoylshikimic acid, quercetin 3-rutinoside, delphinidin 3-sambubioside, and cyanidin 3-sambubioside.
Ingestion of the extract significantly reduced the captopril area under the curve (AUC)0−t (0.1745 (0.1254–0.2429)), AUC0−∞ (0.1734 (0.1232–0.2442))], and peak plasma concentration (0.2119 (0.1337–0.3359)) (geometric mean ratio of the coadministration group to the captopril group (90% CI)).
The geometric mean ratios were falling outside the 90% CI of 0.8–1.25 bioequivalent range.
Conversely, H.
sabdariffa L.
extract increased the apparent total body clearance (Cl/F, 0.0257 ± 0.0115 vs.
0.1418 ± 0.0338 mL/h·kg) and the apparent volume of distribution (Vd/F, 0.0541 ± 0.0226 vs.
0.3205 ± 0.0790 mL/kg).
This study indicated that coadministration of H.
sabdariffa L.
aqueous extract could change the pharmacokinetic profile of captopril; therefore, its coadministration should be avoided.
American Psychological Association (APA)
Nurfaradilla, Shinta Ayu& Saputri, Fadlina Chany& Harahap, Yahdiana. 2020. Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156359
Modern Language Association (MLA)
Nurfaradilla, Shinta Ayu…[et al.]. Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156359
American Medical Association (AMA)
Nurfaradilla, Shinta Ayu& Saputri, Fadlina Chany& Harahap, Yahdiana. Pharmacokinetic Herb-Drug Interaction between Hibiscus sabdariffa Calyces Aqueous Extract and Captopril in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156359