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Protective Role of Loranthus regularis against Liver Dysfunction, Inflammation, and Oxidative Stress in Streptozotocin Diabetic Rat Model
Joint Authors
Mothana, Ramzi A.
Alqahtani, Faleh
Al-Rejaie, Salim S.
Alanazi, Ahmed Z.
Mohany, Mohamed
Abuohashish, Hatem M.
Ahmed, Mohammed M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Earlier studies revealed the potential therapeutic values of Loranthus regularis (L.
regularis).
This study evaluated Loranthus regularis (L.
regularis) extract systemic antidiabetic effects and benefits against diabetic hepatocellular injuries through antioxidant and anti-inflammatory pathways using the streptozotocin (STZ) model in Wistar albino rats.
After diabetes induction, animals were orally treated with L.
regularis extract for 4 weeks.
Serum levels of glucose, insulin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were estimated.
Furthermore, tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), caspase-3, nitric oxide (NO), and prostaglandin E-2 (PGE-2) were estimated in serum.
In liver, thiobarbituric acid reactive substances (TBARSs) and reduced glutathione (GSH) as well as the proinflammatory cytokines and enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reeducates (GR), and glutathione-S-transferase (GST) were assayed.
Finally, the degree of hepatic tissue damage was evaluated histologically.
Treatment of the diabetic rats with L.
regularis extract markedly reduced the elevated serum levels of glucose, ALT, AST, TC, TG, LDL, TNF-α, IL-1β, IL-6, caspase-3, NO, and PGE-2.
L.
regularis extract also improved serum levels of insulin and HDL.
The elevated TBARS, TNF-α, IL-1β, and IL-6 levels in hepatic tissue of diabetic animals were reduced by L.
regularis.
Moreover, L.
regularis extract significantly restored the diminished hepatic GSH level and enzymatic activities of SOD, CAT, GPx, GR, and GST in diabetic animals.
The biochemical protective effects of L.
regularis were associated with improved histological hepatocellular integrity and architecture.
Taken together, L.
regularis has therapeutic effects against diabetic-induced hepatic complications.
The restored liver functions and cellular damage might be mediated through free radicals scavenging and proinflammatory cytokine inhibition.
American Psychological Association (APA)
Alanazi, Ahmed Z.& Alqahtani, Faleh& Mothana, Ramzi A.& Mohany, Mohamed& Abuohashish, Hatem M.& Ahmed, Mohammed M.…[et al.]. 2020. Protective Role of Loranthus regularis against Liver Dysfunction, Inflammation, and Oxidative Stress in Streptozotocin Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156363
Modern Language Association (MLA)
Alanazi, Ahmed Z.…[et al.]. Protective Role of Loranthus regularis against Liver Dysfunction, Inflammation, and Oxidative Stress in Streptozotocin Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156363
American Medical Association (AMA)
Alanazi, Ahmed Z.& Alqahtani, Faleh& Mothana, Ramzi A.& Mohany, Mohamed& Abuohashish, Hatem M.& Ahmed, Mohammed M.…[et al.]. Protective Role of Loranthus regularis against Liver Dysfunction, Inflammation, and Oxidative Stress in Streptozotocin Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156363