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Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating AktmTOR Signaling
Joint Authors
Zhang, Hongcheng
Peng, Wenjun
Liu, Yinkang
Liang, Xiali
Zhang, Gensheng
Kong, Lingjie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Insulin resistance has a critical role in type 2 diabetes.
The aim of this study was to investigate the effect of pinobanksin, galangin, chrysin, and pinocembrin from propolis on insulin resistance.
Our study shows that galangin and pinocembrin can ameliorate insulin resistance; on the contrary, pinobanksin and chrysin are ineffective.
Galangin and pinocembrin treatments substantially increase glucose consumption and glycogen content by enhancing the activities of hexokinase and pyruvate kinase.
Galangin treatment with 80 μM increased hexokinase and pyruvate kinase activities by 21.94% and 29.12%, respectively.
Moreover, we hypothesize that galangin and pinocembrin may have a synergistic effect on the improvement of insulin resistance via Akt/mTOR signaling pathway, through distinctly upregulating the phosphorylation of IR, Akt, and GSK3β and remarkably downregulating the phosphorylation of IRS.
Most notably, this is the first study to our knowledge to investigate pinocembrin about the alleviation of insulin resistance.
Our results provide compelling evidence for the depth development of propolis products to ameliorate insulin resistance.
American Psychological Association (APA)
Liu, Yinkang& Liang, Xiali& Zhang, Gensheng& Kong, Lingjie& Peng, Wenjun& Zhang, Hongcheng. 2018. Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating AktmTOR Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156371
Modern Language Association (MLA)
Liu, Yinkang…[et al.]. Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating AktmTOR Signaling. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156371
American Medical Association (AMA)
Liu, Yinkang& Liang, Xiali& Zhang, Gensheng& Kong, Lingjie& Peng, Wenjun& Zhang, Hongcheng. Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating AktmTOR Signaling. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156371