Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells
Joint Authors
Kim, Jee Young
Dao, Thien T. P.
Song, Kwangho
Park, Sait Byul
Jang, Hyeri
Park, Min Kyoung
Gan, Soo Ueng
Kim, Yeong Shik
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Annona muricata L., known as graviola, is an evergreen plant of the tropical regions and is a rich source of natural products.
Graviola has various biological activities, and it is best known for its anticancer activity.
This study aimed to investigate the effects of crude graviola extract in vitro on breast cancer cells; in particular, we aimed to identify an agent against triple negative breast cancer (TNBC).
We used the TNBC MDA-MB-231 cell line as the experimental model and the ER(+) non-TNBC MCF-7 breast cancer cell line as the control.
We identified annonaceous acetogenins, including annonacin isomers, characteristic to this plant by using liquid chromatography tandem mass spectrometry (LC/MS/MS).
We observed a significant decrease in the cell viability in both cell lines within 48 h, whereas impaired cell motility and invasiveness were observed only in the MDA-MB-231 cell line.
While the MCF-7 cells showed an ER-dependent mechanism of apoptosis, the apoptosis of MDA-MB-231 cells was governed by an intrinsic apoptotic pathway triggered by graviola leaf extract (GLE).
American Psychological Association (APA)
Kim, Jee Young& Dao, Thien T. P.& Song, Kwangho& Park, Sait Byul& Jang, Hyeri& Park, Min Kyoung…[et al.]. 2018. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156377
Modern Language Association (MLA)
Kim, Jee Young…[et al.]. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156377
American Medical Association (AMA)
Kim, Jee Young& Dao, Thien T. P.& Song, Kwangho& Park, Sait Byul& Jang, Hyeri& Park, Min Kyoung…[et al.]. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156377