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Effects of Xin-Ji-Er-Kang on Anticardiovascular Remodeling in L-NAME Induced Hypertensive Mice and Its Potential Mechanisms
Joint Authors
Cheng, Pan
Cai, Guo-wei
Huang, Guang-yao
Gao, Shan
Wang, Li
Ding, Ling
Hu, Juan
Zhang, Yong-xue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Xin-Ji-Er-Kang (XJEK) shows protective effects on the myocardial ischemic diseases in our previous reports.
We hypothesized that XJEK may exert preventing effects on L-NAME induced hypertensive mice by ameliorating oxidative stress (OS) and endothelial dysfunction (ED).
Methods.
After treatment with XJEK for four weeks, cardiac function and cardiovascular pathology changes were evaluated.
Then, endothelial-dependent vascular relaxation and serum NO, eNOS, AMDA, SOD, MDA content, and cardiac tissue eNOS expression were detected.
Results.
The hypertensive mice displayed distinct cardiovascular remodeling including increased HW/BW index (4.7 ± 0.33 versus 5.2 ± 0.34), cross-section area, and collagen deposition.
In addition, ED was found manifested by decreased serum NO (20.54 ± 8.05 versus 6.29 ± 2.33), eNOS (28.34 ± 2.36 versus 20.37 ± 2.30), content, and decreased eNOS expression in cardiac tissue and damaged endothelium-dependent diastolic function.
Moreover, OS was detected confirmed by decreased SOD activity and increased MDA content in serum.
However, treatment with XJEK for 4 wk could reverse cardiovascular remodeling (HW/BW index normalized from 5.2 ± 0.34 to 4.59 ± 0.25), ameliorate and preserve endothelial function (NO: 16.67 ± 7.24 versus 6.29 ± 2.33; eNOS: 16.67 ± 7.24 versus 6.29 ± 2.33), and suppress OS.
Conclusion.
XJEK has protective effects against cardiovascular remodeling in L-NAME induced hypertensive mice.
American Psychological Association (APA)
Wang, Li& Cai, Guo-wei& Ding, Ling& Hu, Juan& Zhang, Yong-xue& Huang, Guang-yao…[et al.]. 2018. Effects of Xin-Ji-Er-Kang on Anticardiovascular Remodeling in L-NAME Induced Hypertensive Mice and Its Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156397
Modern Language Association (MLA)
Wang, Li…[et al.]. Effects of Xin-Ji-Er-Kang on Anticardiovascular Remodeling in L-NAME Induced Hypertensive Mice and Its Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156397
American Medical Association (AMA)
Wang, Li& Cai, Guo-wei& Ding, Ling& Hu, Juan& Zhang, Yong-xue& Huang, Guang-yao…[et al.]. Effects of Xin-Ji-Er-Kang on Anticardiovascular Remodeling in L-NAME Induced Hypertensive Mice and Its Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156397