Vitamin D Deficiency Is Associated with Endoscopic Severity in Patients with Crohn’s Disease
Joint Authors
Ye, Lingna
Cao, Qian
Liu, Jing
Lin, Ziwen
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Aims.
Vitamin D deficiency is common in patients with Crohn’s disease and is associated with disease activity.
Relationship between vitamin D and endoscopic disease activity is unknown.
The aim of the study is to determine the association between vitamin D status and endoscopic disease activity in CD patients.
Methods.
Consecutive hospitalized CD patients from 2014 to 2016 who received vitamin D assessment and colonoscopy were retrospectively evaluated.
Clinical disease activity was assessed by Crohn’s disease activity index and C-reactive protein.
Endoscopic activity was calculated using simple endoscopic score for Crohn’s disease.
Results.
Median serum 25OHD level of 131 patients was lower than healthy controls [21.1 nmol/L (11.8–32.3) versus 49.9 nmol/L (44.9–57.4), P=0.007].
125 (95%) patients had vitamin D deficiency and the rest (5%) had vitamin D insufficiency.
Serum 25OHD was inversely correlated with CRP (r=−0.308, P<0.001), CDAI (r=−0.582, P<0.001), SES-CD (r=−0.294, P=0.001), and endoscopic severity stratified by SES-CD (P=0.001).
Conclusion.
Vitamin D deficiency was prevalent among hospitalized CD patients.
Vitamin D levels were inversely correlated with endoscopic disease activity.
Vitamin D status could be a biomarker in assessing disease activity among hospitalized CD patients in addition to CDAI and CRP.
American Psychological Association (APA)
Ye, Lingna& Lin, Ziwen& Liu, Jing& Cao, Qian. 2017. Vitamin D Deficiency Is Associated with Endoscopic Severity in Patients with Crohn’s Disease. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156413
Modern Language Association (MLA)
Ye, Lingna…[et al.]. Vitamin D Deficiency Is Associated with Endoscopic Severity in Patients with Crohn’s Disease. Gastroenterology Research and Practice No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1156413
American Medical Association (AMA)
Ye, Lingna& Lin, Ziwen& Liu, Jing& Cao, Qian. Vitamin D Deficiency Is Associated with Endoscopic Severity in Patients with Crohn’s Disease. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156413