Immunostimulatory Effect of Zanthoxylum schinifolium-Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats
Joint Authors
Kim, Min Jung
Yang, Hye Jeong
Lee, Hak Yong
Park, Young Mi
Lee, Yang Hee
Kang, Yang Gyu
Lee, Hyang Man
Park, Deuk Seon
Lee, Young-Rae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Complex oil of Zanthoxylum schinifolium and Perilla frutescens seed (ZPCO) is used as a traditional medicine due to its pharmacological activities.
The aim of this study was to investigate the immunostimulatory effect of ZPCO in isolated splenocytes as well as in an immunosuppressed rat model, which was generated via oral administration of cyclophosphamide.
Notably, our results showed that ZPCO exerted an immunity-enhancing effect both in vitro and in vivo.
Specifically, ZPCO treatment enhanced the viability and inflammatory cytokine production of splenocytes and NK cell activity in vitro.
Moreover, this product improved host defense under immunosuppressive conditions by increasing the number of immune cells and promoting the expression of cytokines involved in immune responses.
Our results suggest that complex oil including Z.
schinifolium should be explored as a novel immunostimulatory agent that could potentially be used for therapeutic purposes or as an ingredient in functional foods.
American Psychological Association (APA)
Lee, Hak Yong& Park, Young Mi& Lee, Yang Hee& Kang, Yang Gyu& Lee, Hyang Man& Park, Deuk Seon…[et al.]. 2018. Immunostimulatory Effect of Zanthoxylum schinifolium-Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156421
Modern Language Association (MLA)
Lee, Hak Yong…[et al.]. Immunostimulatory Effect of Zanthoxylum schinifolium-Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156421
American Medical Association (AMA)
Lee, Hak Yong& Park, Young Mi& Lee, Yang Hee& Kang, Yang Gyu& Lee, Hyang Man& Park, Deuk Seon…[et al.]. Immunostimulatory Effect of Zanthoxylum schinifolium-Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156421