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Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in LepobLepob Mice
Joint Authors
Lee, Byung-Cheol
Lee, Daeun
Yoo, Jung Hwa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM).
Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people.
It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by changes in composite ions in the gut microbiome.
This experimental study was designed to investigate the effects of Cucumis melo L.
(Cucumis) on obesity-induced IR in genetically leptin-deficient Lepob/Lepob mice.
Specifically, we examined the anti-inflammatory effects of Cucumis and the effects of Cucumis on the gut microbiota.
We evaluated glucose control by measuring FBS, performing the OGTT, quantifying serum IR, calculating the HOMA-IR, and determining the lipid profiles.
To see whether inflammation was reduced, we analyzed adipose tissue macrophages as well as monocytes in the blood.
We also profiled the gut microbiota to determine whether the ratios of microbial phyla changed.
We found that Cucumis improved IR in obese mice and relieved inflammation in adipose tissue and blood.
Simultaneously, the microbiota composition ratios changed.
In conclusion, administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition.
Cucumis is thus a promising treatment for obesity-induced insulin resistance and the inflammatory state.
American Psychological Association (APA)
Lee, Daeun& Yoo, Jung Hwa& Lee, Byung-Cheol. 2018. Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in LepobLepob Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156446
Modern Language Association (MLA)
Lee, Daeun…[et al.]. Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in LepobLepob Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156446
American Medical Association (AMA)
Lee, Daeun& Yoo, Jung Hwa& Lee, Byung-Cheol. Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in LepobLepob Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156446