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Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10
Joint Authors
Lee, Jeong-won
Seok, Jin Kyung
Boo, Yong Chool
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Airborne particulate matter can cause oxidative stress, inflammation, and premature skin aging.
Marine plants such as Ecklonia cava Kjellman contain high amounts of polyphenolic antioxidants.
The purpose of this study was to examine the antioxidative effects of E.
cava extract in cultured keratinocytes exposed to airborne particulate matter with a diameter of <10 μm (PM10).
After the exposure of cultured HaCaT keratinocytes to PM10 in the absence and presence of E.
cava extract and its constituents, cell viability and cellular lipid peroxidation were assessed.
The effects of eckol and dieckol on cellular lipid peroxidation and cytokine expression were examined in human epidermal keratinocytes exposed to PM10.
The total phenolic content of E.
cava extract was the highest among the 50 marine plant extracts examined.
The exposure of HaCaT cells to PM10 decreased cell viability and increased lipid peroxidation.
The PM10-induced cellular lipid peroxidation was attenuated by E.
cava extract and its ethyl acetate fraction.
Dieckol more effectively attenuated cellular lipid peroxidation than eckol in both HaCaT cells and human epidermal keratinocytes.
Dieckol and eckol attenuated the expression of inflammatory cytokines such as tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-8 in human epidermal keratinocytes stimulated with PM10.
This study suggested that the polyphenolic constituents of E.
cava, such as dieckol, attenuated the oxidative and inflammatory reactions in skin cells exposed to airborne particulate matter.
American Psychological Association (APA)
Lee, Jeong-won& Seok, Jin Kyung& Boo, Yong Chool. 2018. Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156473
Modern Language Association (MLA)
Lee, Jeong-won…[et al.]. Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156473
American Medical Association (AMA)
Lee, Jeong-won& Seok, Jin Kyung& Boo, Yong Chool. Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156473