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Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats
Joint Authors
Fan, Yongsheng
Xu, Li
Mei, Lijun
Lin, Chen
Lei, Shanshan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Agkistrodon in Chinese medicine has long been used as an effective treatment against rheumatoid arthritis (RA).
The present research further investigated the effects of peptides extracted from the crude Agkistrodon on the RA rat model.
Extracted peptides were separated by parameter-optimized ion-exchange chromatography (IEC), peptide fractions were further analysed by MALDI-TOF/TOF MS, and nano-LC-MS/MS acquired mass spectra were further characterized using Mascot software, which ranks the best matches in the NCBI database.
RT-PCR results in RAW264.7 cells indicated that Agkistrodon peptide components had inhibitory effects against inflammatory cytokines.
The therapeutic efficacy of Agkistrodon peptides was evaluated on the Wistar rats with collagen-induced arthritis.
Symptom relief and reduced cartilage destruction and bone erosion were observed, which can be explained by the direct suppression of inflammatory cytokines in the joints.
Agkistrodon peptides downregulate the expression of TNF-α, IL-1β, and IL-6, which may alleviate cartilage destruction and bone erosion, thus relieving symptoms of RA.
American Psychological Association (APA)
Mei, Lijun& Lin, Chen& Lei, Shanshan& Xu, Li& Fan, Yongsheng. 2018. Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156485
Modern Language Association (MLA)
Mei, Lijun…[et al.]. Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156485
American Medical Association (AMA)
Mei, Lijun& Lin, Chen& Lei, Shanshan& Xu, Li& Fan, Yongsheng. Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156485