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Gundelia tournefortii Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation
Joint Authors
Zaid, Hilal
Kadan, Sleman
Saad, Bashar
Sasson, Yoel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the present in vitro study, we tested the chemical composition, cytotoxicity and antidiabetic activity of two distinct extracts of wild Artichoke-like vegetable, Gundelia tournefortii: methanol and hexane.
GC/MS phytochemical analysis of G.
tournefortii methanol and hexane extracts revealed 39 compounds reported here for the first time in G.
tournefortii out of the 45 detected compounds.
Only Stigmasterol was present in both extracts.
The efficacy of G.
tournefortii extracts in enhancing glucose transporter 4 (GLUT4) translocation to the plasma membrane (PM) was tested in L6 muscle cells stably expressing myc-tagged GLUT4 (L6-GLUT4myc) using cell-ELISA test.
Results obtained here indicate that methanol and hexane extracts were safe up to 250 μg/ml as measured with MTT and the LDH leakage assays.
The methanol extract was the most efficient in GLUT4 translocation enhancement.
It increased GLUT4 translocation at 63 μg/ml 1.5- and 2-fold relative to the control in the absence and presence of insulin, respectively.
These findings indicate that G.
tournefortii possesses antidiabetic activity in part by enhancing GLUT4 translocation to the PM in skeletal muscle.
American Psychological Association (APA)
Kadan, Sleman& Sasson, Yoel& Saad, Bashar& Zaid, Hilal. 2018. Gundelia tournefortii Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156489
Modern Language Association (MLA)
Kadan, Sleman…[et al.]. Gundelia tournefortii Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156489
American Medical Association (AMA)
Kadan, Sleman& Sasson, Yoel& Saad, Bashar& Zaid, Hilal. Gundelia tournefortii Antidiabetic Efficacy: Chemical Composition and GLUT4 Translocation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156489