Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity
Joint Authors
Seneviratne, B.
Gunasekara, Chinthika
Weerasekera, Manjula
Fernando, Neluka
Arachchi, Piyumali Sandareka
Weerasekera, Deepaka D.
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The pro- and anti-inflammatory cytokines play an important role in the immune response against H.
pylori infection.
The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H.
pylori infection and resulting gastric inflammation.
Objective.
The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H.
pylori-infected patients and healthy controls and to understand their association with H.
pylori infection and disease severity.
Results.
The expression levels of IL-17 and IL-23 were significantly higher in H.
pylori-infected patients.
The expression of IL-21 was also higher in H.
pylori-positive patients but there was no significant association with infection.
IL-17 expression showed a significant increase with the severity of chronic gastritis.
Conclusion.
The proinflammatory cytokine, IL-17, shows a significant association with H.
pylori infection and disease severity in a Sri Lankan dyspeptic patient population.
American Psychological Association (APA)
Arachchi, Piyumali Sandareka& Fernando, Neluka& Weerasekera, Manjula& Seneviratne, B.& Weerasekera, Deepaka D.& Gunasekara, Chinthika. 2017. Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156511
Modern Language Association (MLA)
Arachchi, Piyumali Sandareka…[et al.]. Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156511
American Medical Association (AMA)
Arachchi, Piyumali Sandareka& Fernando, Neluka& Weerasekera, Manjula& Seneviratne, B.& Weerasekera, Deepaka D.& Gunasekara, Chinthika. Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156511
