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TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma
Joint Authors
Zhou, Lin
Liu, Zhikun
Gao, Feng
Shao, Zhou
Xu, Xiao
Zheng, Shu-Sen
Xie, Haiyang
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
TFCP2 is an oncogene and plays crucial roles in the incidence and progression of hepatocellular carcinoma (HCC).
However, no reports are available on the impact of TFCP2 genetic polymorphism on the susceptibility to and the transplant prognosis of HCC.
Here, we genotyped 7 SNPs of TFCP2 in a case-control study of 119 patients with HCC and 200 patients with chronic liver disease.
Of the 7 SNPs in TFCP2, rs7959378 distributed differentially between patients with versus patients without HCC.
The patients with the CA (OR = 0.58, 95% CI = 0.35–0.96), the CC (OR = 0.39, 95% CI = 0.20–0.76), and the CA/CC (OR = 0.52, 95% CI = 0.32–0.83) genotypes had significantly decreased risk for HCC compared with those carrying the rs7959378 AA genotype.
After adjusting for confounding factors, rs7959378 still conferred significant risk for HCC.
Furthermore, the patients who carried rs7959378 AC/CC had a higher overall survival and lower relapse-free survival than those with the rs7959378 AA genotype.
Similar results were found in the multivariate analysis adjusted by AFP, tumor size and tumor number, and differentiation.
These findings indicate that rs7959378 is associated with the risk of HCC in patient with chronic liver disease and prognosis of HCC patients after liver transplantation.
American Psychological Association (APA)
Liu, Zhikun& Gao, Feng& Shao, Zhou& Xie, Haiyang& Zhou, Lin& Xu, Xiao…[et al.]. 2017. TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156519
Modern Language Association (MLA)
Liu, Zhikun…[et al.]. TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156519
American Medical Association (AMA)
Liu, Zhikun& Gao, Feng& Shao, Zhou& Xie, Haiyang& Zhou, Lin& Xu, Xiao…[et al.]. TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156519