Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.)‎ in a Preclinical Model of Lipotoxicity and Dyslipidemia

Joint Authors

Novaes, Rômulo Dias
Reis, Mayara Áthina
Baggio, Sueli Regina
Viana, André Luiz Machado
Salles, Bruno Cesar Correa
Duarte, Stella Maris da Silveira
Rodrigues, Maria Rita
Paula, Fernanda Borges de Araújo

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-10-02

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

The oil obtained from baru (Dipteryx alata Vog.) almonds exhibits high energy value and is reported in popular medicine for the treatment of rheumatic diseases and reproductive disturbances.

Although baru oil is used in domestic cuisine, the chemical characterization of this oil and its effects on lipid metabolism are still poorly understood.

Therefore, this study evaluated the fatty acid (FA) profile and the effects of baru oil on liver and aorta in a murine model of dyslipidemia.

The chromatographic profile of baru oil showed high levels of unsaturated FAs, especially oleic acid.

Saturated FAs, such as palmitic and lignoceric acids, were found in lower amounts.

Hypercholesterolemia was induced in male Wistar rats by daily administration of a lipid emulsion by gavage for 15 weeks.

Biochemical and histopathological analysis were performed on serum, aorta, and liver.

The results demonstrated that animals developed marked hypercholesterolemia, liver steatosis, and increased lipid peroxidation in the aorta.

Treatment with baru oil attenuated lipid peroxidation and drastically reduced liver damage, especially ballooning degeneration and steatosis.

By restricting vascular and hepatic injury, this oil showed potential applicability as a functional food, reinforcing its use in popular medicine and domestic cuisine.

American Psychological Association (APA)

Reis, Mayara Áthina& Novaes, Rômulo Dias& Baggio, Sueli Regina& Viana, André Luiz Machado& Salles, Bruno Cesar Correa& Duarte, Stella Maris da Silveira…[et al.]. 2018. Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156521

Modern Language Association (MLA)

Reis, Mayara Áthina…[et al.]. Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156521

American Medical Association (AMA)

Reis, Mayara Áthina& Novaes, Rômulo Dias& Baggio, Sueli Regina& Viana, André Luiz Machado& Salles, Bruno Cesar Correa& Duarte, Stella Maris da Silveira…[et al.]. Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156521

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1156521