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Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay
Joint Authors
Cai, Zhe
Wang, Qi
Song, Lei
Hong, Ming
Liu, Yongqiang
Feng, Xiangfei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in developed countries.
Oxidative stress plays a critical role in the progression of NAFLD.
Modern pharmacological study and clinical trials have demonstrated the remarkable antioxidant activity of Gynostemma pentaphyllum (GP) in chronic liver disease.
One aim of this study was to explore the potential protective effects and mechanisms of action of GP extract on NAFLD.
The in vivo results showed that GP extract could alleviate fatty degeneration and haptic fibrosis in NAFLD mice.
For exploring the hepatoprotective mechanisms of GP, we used network pharmacology to predict the potential active components of GP and their intracellular targets in NAFLD.
Based on the network pharmacology results, we further utilized biomedical assays to validate this in silico prediction.
The results showed that Gypenoside XL could upregulate the protein level of PPARα in NAFLD; the transcription level of several PPARα downstream target genes such as acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase-1 (CPT-1) also increased after Gypenoside XL treatment.
The overexpression of ACO and CPT-1 may involve the hepatoprotective effects of GP and Gypenoside XL on NAFLD by regulating mitochondrial fatty acid β-oxidation.
American Psychological Association (APA)
Hong, Ming& Cai, Zhe& Song, Lei& Liu, Yongqiang& Wang, Qi& Feng, Xiangfei. 2018. Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156527
Modern Language Association (MLA)
Hong, Ming…[et al.]. Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156527
American Medical Association (AMA)
Hong, Ming& Cai, Zhe& Song, Lei& Liu, Yongqiang& Wang, Qi& Feng, Xiangfei. Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156527