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A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer
Joint Authors
Pellino, Gianluca
Fiorentino, Francesca
Qiu, Shengyang
Rasheed, Shahnawaz
Kontovounisios, Christos
Tekkis, Paris P.
Darzi, Ara
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract.
In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers.
In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells.
There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC.
Furthermore, blockade and modulation of the NTS/NTSR signalling pathways appears to reduce CRC growth in cell cultures and animal studies.
Lastly, NTS/NTSR also shows potential of being utilised as a diagnostic biomarker for cancers as well as targets for functional imaging.
We summarise the existing evidence and understanding of the role of NTS and its receptors in CRC.
American Psychological Association (APA)
Qiu, Shengyang& Pellino, Gianluca& Fiorentino, Francesca& Rasheed, Shahnawaz& Darzi, Ara& Tekkis, Paris P.…[et al.]. 2017. A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156529
Modern Language Association (MLA)
Qiu, Shengyang…[et al.]. A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156529
American Medical Association (AMA)
Qiu, Shengyang& Pellino, Gianluca& Fiorentino, Francesca& Rasheed, Shahnawaz& Darzi, Ara& Tekkis, Paris P.…[et al.]. A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156529