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Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology
Joint Authors
Chen, Junmin
Chen, Jianyong
Lu, Jingrong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oroxylum indicum (O.
indicum) is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities.
However, the pharmacological effect of O.
indicum and its mechanism of action have not to be systematically elucidated yet.
In this study, the druggability for active compounds of O.
indicum was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential drug targets of O.
indicum were identified using PharmMapper database.
Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via WebGestalt.
Drug-target-pathway networks were constructed using Cytoscape to give a visual view.
Our findings revealed that O.
indicum has extremely superb druggability with 41 putative identified target genes.
GO, KEGG, and network analyses showed that these targets were associated with inflammatory immunoreactions, cancer, and other biological processes.
In summary, O.
indicum is predicted to target multiple genes/proteins and pathways that shape a network which can exert systematic pharmacological effects.
American Psychological Association (APA)
Chen, Junmin& Chen, Jianyong& Lu, Jingrong. 2020. Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156531
Modern Language Association (MLA)
Chen, Junmin…[et al.]. Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156531
American Medical Association (AMA)
Chen, Junmin& Chen, Jianyong& Lu, Jingrong. Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156531