The Role of Xuefu Zhuyu Decoction in Prevention of Contrast-Induced Nephropathy after Percutaneous Coronary Intervention
Joint Authors
Zhao, Jingjing
Liu, Huahua
Xu, Buyun
Peng, Jiahao
Xing, Yangbo
Tang, Weiliang
Peng, Fang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
This study aimed to investigate the effect of Xuefu Zhuyu decoction on preventing contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI).
Methods.
A total of 256 patients undergoing selective PCI for coronary artery disease were consecutively enrolled and randomly divided into two groups: Group A (n = 126) and Group B (n = 130).
Before and after PCI, all patients routinely received antiplatelet aggregation therapy, antilipidemic therapy, and hydration therapy.
Besides routine therapy, patients in Group B received Xuefu Zhuyu decoction from 3 days before PCI to 3 days after PCI.
Serum creatinine (Scr), estimated glomerular filtration rate (eGFR), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured, respectively, at baseline (72 h before PCI) and at 24, 48, and 72 h after PCI.
Results.
Compared with Group A, Group B presented a lower fluctuation of SCr and eGFR (P<0.01).
The incidence of CIN was less in Group B.
According to the definition, CIN occurred in 5 patients (2.0%) in the intervention group and 5 (4.0%) in the control group (P=0.167).
In terms of oxidative stress, Group B had a lower MDA (P<0.05), but a higher SOD (P<0.05).
Conclusions.
Compared with the control group, Xuefu Zhuyu decoction intervention therapy increased the level of SOD and reduced MDA.
The Xuefu Zhuyu decoction intervention group presented a higher level of eGFR at 24, 48, and 72 h after PCI in patients with coronary heart disease and a lower level of Scr.
The results are propitious to prove that Xuefu Zhuyu decoction might play an antioxidative stress role in the prevention of CIN after PCI.
American Psychological Association (APA)
Zhao, Jingjing& Liu, Huahua& Xu, Buyun& Peng, Jiahao& Xing, Yangbo& Tang, Weiliang…[et al.]. 2020. The Role of Xuefu Zhuyu Decoction in Prevention of Contrast-Induced Nephropathy after Percutaneous Coronary Intervention. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156570
Modern Language Association (MLA)
Zhao, Jingjing…[et al.]. The Role of Xuefu Zhuyu Decoction in Prevention of Contrast-Induced Nephropathy after Percutaneous Coronary Intervention. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1156570
American Medical Association (AMA)
Zhao, Jingjing& Liu, Huahua& Xu, Buyun& Peng, Jiahao& Xing, Yangbo& Tang, Weiliang…[et al.]. The Role of Xuefu Zhuyu Decoction in Prevention of Contrast-Induced Nephropathy after Percutaneous Coronary Intervention. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156570