Immunomodulatory and Antioxidant Activities of a Polysaccharide from Ligustrum vicaryi L. Fruit
Joint Authors
Liu, Shuling
Wang, Litao
Ren, Qiang
Wang, Jianan
Li, Yanzhi
Wang, Guanghui
Gao, Huijie
Du, Rui
Qin, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ligustrum vicaryi L.
is a hybrid of Ligustrum ovalifolium Hassk.
var.
aureo-marginatum and Ligustrum vulgale L., belonging to the Oleaceae family.
It is often used as an ornamental shrub due to its golden leaves.
However, its medical value is yet to be discovered.
Recently, plant polysaccharides have attracted comprehensive attention owing to their biological properties, including immunomodulatory and antioxidant activities.
This study aimed to extract, purify, and characterize the polysaccharide from the Ligustrum vicaryi L.
fruit and investigate its immunomodulatory and antioxidant activities.
The Ligustrum vicaryi L.
fruit polysaccharide (LVFP) was obtained by ultrasonic extraction, ethanol precipitation, macroporous resin separation, and dialysis bag purification.
The physicochemical properties of the LVFP were elucidated using Fourier-transform infrared spectrometry, high-performance ion chromatography, and high-performance gel filtration chromatography.
The results indicated that the LVFP consisted of rhamnose, arabinose, galactose, and glucose in a ratio of 1.79 : 7.55 : 4.58 : 1.54, and its molecular weight was 88,949 Da.
The immunomodulatory and antioxidant activities of the LVFP were investigated using a cyclophosphamide- (Cy-) induced immunosuppressed mouse model.
The results demonstrated that the LVFP significantly increased spleen and thymus indexes, enhanced the phagocytic function of neutrophils, activated B and T lymphocytes, and upregulated serum levels of IL-10 and TNF-α.
Moreover, we observed that the LVFP relieved Cy-induced liver damage by increasing superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) levels.
These results suggested that the LVFP has the immunomodulatory and antioxidant activities, therefore laying a foundation for the application of the LVFP in the pharmaceutical and functional food industries.
American Psychological Association (APA)
Liu, Shuling& Wang, Litao& Ren, Qiang& Wang, Jianan& Li, Yanzhi& Wang, Guanghui…[et al.]. 2020. Immunomodulatory and Antioxidant Activities of a Polysaccharide from Ligustrum vicaryi L. Fruit. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156573
Modern Language Association (MLA)
Liu, Shuling…[et al.]. Immunomodulatory and Antioxidant Activities of a Polysaccharide from Ligustrum vicaryi L. Fruit. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156573
American Medical Association (AMA)
Liu, Shuling& Wang, Litao& Ren, Qiang& Wang, Jianan& Li, Yanzhi& Wang, Guanghui…[et al.]. Immunomodulatory and Antioxidant Activities of a Polysaccharide from Ligustrum vicaryi L. Fruit. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156573