Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation
Joint Authors
Hong, Ki-Bae
Jang, Eun Yeong
Ahn, Yejin
Suh, Hyung Joo
Jo, Kyungae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Constipation is a chronic disease caused by infrequent, inadequate, and difficult bowel movements.
The present study aimed to evaluate the potential laxative effect of maltooligosaccharide (MOS) on loperamide-induced constipation in a rat model.
In vitro experiments were conducted to evaluate the effect of MOS on the growth of lactic acid bacteria.
Moreover, to examine the effect of MOS administration on Sprague-Dawley (SD) rats with loperamide-induced constipation, the drinking water for the rats was supplemented with 10% or 15% of MOS for 14 days, and, thereafter, the improvement in constipation was assessed.
For this, the rats were divided into five groups: normal (Nor), loperamide-induced constipated (Con), positive control (15% of dual-oligosaccharide (DuO-15)), 10% MOS treated (MOS-10), and 15% MOS-treated (MOS-15).
In an in vitro test, MOS treatment promoted the growth of lactic acid bacteria except Lactobacillus bulgaricus.
Treatment with higher MOS dose relieved constipation in rats by improving the fecal pellet and water content.
Furthermore, in the high MOS dose group, the cecal short-chain fatty acid levels significantly increased compared to those in the control group (P<0.001).
MOS treatment also improved the mucosal thickness as well as mucin secretion and increased the area of intestinal Cajal cells compared to that in the control group (P<0.001).
These findings suggest that MOS relieves constipation and has beneficial effect on the gastrointestinal tract, and, therefore, it can be used as an ingredient in functional foods for treating constipation or improving intestinal health.
American Psychological Association (APA)
Jang, Eun Yeong& Ahn, Yejin& Suh, Hyung Joo& Hong, Ki-Bae& Jo, Kyungae. 2020. Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156580
Modern Language Association (MLA)
Jang, Eun Yeong…[et al.]. Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156580
American Medical Association (AMA)
Jang, Eun Yeong& Ahn, Yejin& Suh, Hyung Joo& Hong, Ki-Bae& Jo, Kyungae. Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156580