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The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metastasis is a highly complicated and sequential process in which primary cancer spreads to secondary organic sites.
Liver is a well-known metastatic organ from colorectal cancer.
Carcinoembryonic antigen (CEA) is expressed in most gastrointestinal, breast, and lung cancer cells.
Overexpression of CEA is closely associated with liver metastasis, which is the main cause of death from colorectal cancer.
CEA is widely used as a diagnostic and prognostic tumor marker in cancer patients.
It affects many steps of liver metastasis from colorectal cancer cells.
CEA inhibits circulating cancer cell death.
CEA also binds to heterogeneous nuclear RNA binding protein M4 (hnRNP M4), a Kupffer cell receptor protein, and activates Kupffer cells to secrete various cytokines that change the microenvironments for the survival of colorectal cancer cells in the liver.
CEA also activates cell adhesion-related molecules.
The close correlation between CEA and cancer has spurred the exploration of many CEA-targeted approaches as anticancer therapeutics.
Understanding the detailed functions and mechanisms of CEA in liver metastasis will provide great opportunities for the improvement of anticancer approaches against colorectal cancers.
In this report, the roles of CEA in liver metastasis and CEA-targeting anticancer modalities are reviewed.
American Psychological Association (APA)
Lee, Joo Han& Lee, Seong-Wook. 2017. The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1156605
Modern Language Association (MLA)
Lee, Joo Han& Lee, Seong-Wook. The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches. Gastroenterology Research and Practice No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1156605
American Medical Association (AMA)
Lee, Joo Han& Lee, Seong-Wook. The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1156605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156605