Chinese Herbal Formula Xuefu Zhuyu for Tension-Type Headache with Qi-Stagnation and Blood-Stasis Pattern (CheruXTH): Study Protocol for a Randomized Controlled Trial
Joint Authors
Zhang, Zhe
Zhou, Li
Wen, Zehuai
Liao, Shaojun
Zhou, Hongfei
Wang, Pengqin
Bai, Li
Liu, Guanghui
Li, Geng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Tension-type headache (TTH) is the most common headache disorder.
Current treatments for TTH have been reported to be associated with insufficient long-term benefits and unwanted adverse events (AEs).
The Chinese herbal formula Xuefu Zhuyu (XFZY) has been utilized in TTH treatment, but the evidence supporting its efficacy remains unclear.
This study will evaluate the efficacy and safety of XFZY for TTH.
Methods.
This multicenter, double-blind, randomized, placebo-controlled trial will be undertaken in China.
A total of 174 eligible participants will be randomly assigned to either an XFZY group or a placebo group (20 ml each dose, three times daily for 4 weeks) at a ratio of 1 : 1.
The primary outcome is the change in mean headache intensity measured by a 10 cm visual analogue scale (VAS).
Secondary outcomes include the area-under-the headache curve (AUC), headache frequency, rescue medication use, qi-stagnation and blood-stasis pattern measurement, quality of life measured by the EuroQol-5-Dimensions-5-Level (EQ-5D-5L), global evaluation of medication, and health economic indexes.
Discussion.
The results of the study are expected to provide evidence of high methodological and reporting quality on the efficacy and safety of XFZY for TTH.
This trail is registered with ChiCTR1900026716 (registered on 19 October, 2019).
American Psychological Association (APA)
Zhou, Li& Zhang, Zhe& Li, Geng& Liao, Shaojun& Zhou, Hongfei& Wang, Pengqin…[et al.]. 2020. Chinese Herbal Formula Xuefu Zhuyu for Tension-Type Headache with Qi-Stagnation and Blood-Stasis Pattern (CheruXTH): Study Protocol for a Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156640
Modern Language Association (MLA)
Zhou, Li…[et al.]. Chinese Herbal Formula Xuefu Zhuyu for Tension-Type Headache with Qi-Stagnation and Blood-Stasis Pattern (CheruXTH): Study Protocol for a Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156640
American Medical Association (AMA)
Zhou, Li& Zhang, Zhe& Li, Geng& Liao, Shaojun& Zhou, Hongfei& Wang, Pengqin…[et al.]. Chinese Herbal Formula Xuefu Zhuyu for Tension-Type Headache with Qi-Stagnation and Blood-Stasis Pattern (CheruXTH): Study Protocol for a Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156640