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Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
Joint Authors
Lu, Jie
Li, Jingjing
Li, Sainan
Liu, Tong
Zhou, Yuqing
Zhang, Rong
Zhou, Shunfeng
Li, Linqiang
Cheng, Keran
Kong, Rui
Xu, Shizan
Feng, Jiao
Wu, Liwei
Xia, Yujing
Zhou, Ying-Qun
Guo, Chuan-Yong
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
The present study was conducted to compare the efficacy of metformin combined with diammonium glycyrrhizinate enteric-coated capsule (DGEC) versus metformin alone versus DGEC alone for the treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Subjects and Methods.
163 patients with NAFLD and T2DM were enrolled in this 24-week study and were randomized to one of three groups: group 1 was treated with metformin alone; group 2 was treated with DGEC alone; group 3 received metformin plus DGEC combination therapy.
Anthropometric parameters, liver function, lipid profile, serum ferritin (SF), metabolic parameters, liver/spleen computed tomography (CT) ratio, and fibroscan value were evaluated at baseline and after 8, 16, and 24 weeks of treatment.
Results.
After 24 weeks, significant improvements in all measured parameters were observed in three groups (P<0.05) except for the improvements in low density lipoprotein cholesterol (LDL-C) and metabolic parameters in group 2 which did not reach statistical significance (P>0.05).
Compared with group 1 and group 2, the patients in group 3 had greater reductions in observed parameters apart from CB and TB (P<0.05).
Conclusions.
This study showed that metformin plus DGEC was more effective than metformin alone or DGEC alone in reducing liver enzymes, lipid levels, and metabolic parameters and ameliorating the degree of hepatic fibrosis in patients with NAFLD and T2DM.
American Psychological Association (APA)
Zhang, Rong& Cheng, Keran& Xu, Shizan& Li, Sainan& Zhou, Yuqing& Zhou, Shunfeng…[et al.]. 2017. Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1156679
Modern Language Association (MLA)
Zhang, Rong…[et al.]. Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Gastroenterology Research and Practice No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1156679
American Medical Association (AMA)
Zhang, Rong& Cheng, Keran& Xu, Shizan& Li, Sainan& Zhou, Yuqing& Zhou, Shunfeng…[et al.]. Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1156679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156679