Hereditary Colorectal Tumors: A Literature Review on MUTYH-Associated Polyposis
Joint Authors
Kantor, Micaella
Sobrado, Javier
Patel, Sima
Eiseler, Sara
Ochner, Christopher
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
MAP (MUTYH-associated polyposis) is a syndrome, described in 2002, which is associated with colorectal adenomas, with enhanced colorectal carcinogenesis.
This review synthesizes the available literature on MAP and outlines its pathogenesis, association with colorectal tumorigenesis, screening, treatment, and the subtle differences between it and its close cousins—FAP and AFAP.
The preponderance of data is collected using MAP guidelines.
However, although AFAP and MAP appear similar, potentially important distinctions exist, warranting targeted diagnostic criteria and treatment approaches.
We suggest that it may be prudent to screen for MAP earlier than in current clinical practice, as it has been shown that sequence variants are associated with more severe disease, presenting with an earlier onset of colorectal cancer.
Finally, we issue a call-to-action for much-needed further data to establish clear clinical and diagnostic criteria.
American Psychological Association (APA)
Kantor, Micaella& Sobrado, Javier& Patel, Sima& Eiseler, Sara& Ochner, Christopher. 2017. Hereditary Colorectal Tumors: A Literature Review on MUTYH-Associated Polyposis. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1156689
Modern Language Association (MLA)
Kantor, Micaella…[et al.]. Hereditary Colorectal Tumors: A Literature Review on MUTYH-Associated Polyposis. Gastroenterology Research and Practice No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1156689
American Medical Association (AMA)
Kantor, Micaella& Sobrado, Javier& Patel, Sima& Eiseler, Sara& Ochner, Christopher. Hereditary Colorectal Tumors: A Literature Review on MUTYH-Associated Polyposis. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1156689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156689