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Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia
Joint Authors
Khedr, Mohamed Ahmed
Goda, Shaimaa Samy
El-Araby, Hanaa Ahmed
Sira, Mostafa Mohamed
El-Shenawy, Soha Z.
Ibrahim, Tarek
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The standard-of-care treatment for biliary atresia (BA) is surgical restoration of bile flow by Kasai portoenterostomy.
We aimed to study serum interleukin- (IL-) 12p40, a natural antagonist for the proinflammatory IL-12p70, and its relation to surgical outcomes of BA.
The study included 75 infants with neonatal cholestasis: BA group (n=25), non-BA cholestasis group (n=30), and neglected BA group (n=20), in addition to thirty healthy neonates serving as controls.
IL-12p40 was measured by ELISA in all individuals and a second assessment was performed 3 months postoperatively in the BA group.
The surgical outcomes were classified as successful (bilirubin ≤ 2 mg/dl) or failed (bilirubin > 2 mg/dl).
IL-12p40 was higher in BA compared to that in the non-BA and control groups (P values were 0.036 and <0.0001, resp.) but comparable to that in the neglected BA group.
Preoperative IL-12p40 levels in BA patients were significantly higher in successful Kasai compared with failed Kasai and a cutoff level of 547.47 pg/ml could predict the successful outcome with 87.5% sensitivity and 82.4% specificity.
Three-month postoperative IL-12p40 tended to decrease in both the successful and failed groups.
In conclusion, preoperative serum IL-12p40 is a potential predictor of Kasai outcome.
Serial postoperative measurements may anticipate the failure of an initially successful operation, hence the need for liver transplantation.
American Psychological Association (APA)
Goda, Shaimaa Samy& Khedr, Mohamed Ahmed& El-Shenawy, Soha Z.& Ibrahim, Tarek& El-Araby, Hanaa Ahmed& Sira, Mostafa Mohamed. 2017. Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156701
Modern Language Association (MLA)
Goda, Shaimaa Samy…[et al.]. Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156701
American Medical Association (AMA)
Goda, Shaimaa Samy& Khedr, Mohamed Ahmed& El-Shenawy, Soha Z.& Ibrahim, Tarek& El-Araby, Hanaa Ahmed& Sira, Mostafa Mohamed. Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156701