The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus
Joint Authors
Zhang, Bo
Li, Jinnan
Feng, Jinlei
Wei, Hong
Liu, Qunying
Yang, Ting
Hou, Shengpan
Zhao, Ying
Yang, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia and dyslipidemia caused by impaired insulin secretion and resistance of the peripheral tissues.
A major pathogenesis of T2DM is obesity-associated insulin resistance.
Gynura divaricata (L.) DC.
(GD) is a natural plant and has been reported to have numerous health-promoting effects on both animals and humans.
In this study, we aimed to elucidate the regulatory mechanism of GD improving glucose and lipid metabolism in an obesity animal model induced by high-fat and high-sugar diet in combination with low dose of streptozocin and an insulin-resistant HepG2 cell model induced by dexamethasone.
The study showed that the water extract of GD (GD extract A) could significantly reduce fasting serum glucose, reverse dyslipidemia and pancreatic damage, and regulate the body weight of mice.
We also found that GD extract A had low toxicity in vivo and in vitro.
Furthermore, GD extract A may increase glucose consumption in insulin-resistant HepG2 cells, markedly inhibit NF-κB activation, and decrease the impairment in signaling molecules of insulin pathway, such as IRS-1, AKT, and GLUT1.
Overall, the results indicate that GD extract A is a promising candidate for the prevention and treatment of T2DM.
American Psychological Association (APA)
Li, Jinnan& Feng, Jinlei& Wei, Hong& Liu, Qunying& Yang, Ting& Hou, Shengpan…[et al.]. 2018. The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156702
Modern Language Association (MLA)
Li, Jinnan…[et al.]. The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156702
American Medical Association (AMA)
Li, Jinnan& Feng, Jinlei& Wei, Hong& Liu, Qunying& Yang, Ting& Hou, Shengpan…[et al.]. The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156702