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The Protective Effect of Shen Qi Wan on Adenine-Induced Podocyte Injury
Joint Authors
Chen, Hongshu
Ji, Liting
Lin, Yiyou
Zhang, Jieying
Fu, Yunbo
Lin, Luning
Yang, Yuanxiao
Li, Changyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Podocytes are a special type of differentiated epithelial cells that maintain the glomerular filtration barrier in the kidney.
Injury or damages in podocytes can cause kidney-related disorders, like CKD.
The injury or dysfunction of podocytes can occur by different metabolic disorders.
Due to the severity and complexity of podocyte injuries, this state is considered as a serious health issue worldwide.
Here, we examined and addressed the efficacy of an alternative Chinese medicine, Shen Qi Wan (SQW), on podocyte-related kidney injury.
We evaluated the role and mechanism of action of SQW in podocyte injury.
We observed that SQW significantly reduced 24-hour urinary protein and blood urea nitrogen levels and alleviated the pathological damage caused by adenine.
Moreover, SQW significantly decreased the expression of nephrin and increased the expression of WT1 and AQP1 in the kidney of mice treated with adenine.
We observed that SQW did not effectively reduce the high level of proteinuria in AQP1−/− mice indicating the prominent role of AQP1 in the SQW-ameliorating pathway.
Transmission electron microscopy (TEM) images indicated the food processes effacement in AQP1−/− mice were not lessened by SQW.
In conclusion, podocyte injury could alter the pathological nature of the kidney, and SQW administration relieves the nature of pathogenesis by activating AQP1.
American Psychological Association (APA)
Lin, Yiyou& Zhang, Jieying& Fu, Yunbo& Ji, Liting& Lin, Luning& Chen, Hongshu…[et al.]. 2020. The Protective Effect of Shen Qi Wan on Adenine-Induced Podocyte Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156716
Modern Language Association (MLA)
Lin, Yiyou…[et al.]. The Protective Effect of Shen Qi Wan on Adenine-Induced Podocyte Injury. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156716
American Medical Association (AMA)
Lin, Yiyou& Zhang, Jieying& Fu, Yunbo& Ji, Liting& Lin, Luning& Chen, Hongshu…[et al.]. The Protective Effect of Shen Qi Wan on Adenine-Induced Podocyte Injury. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156716