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Feasibility of Short-Period, High-Dose Intravenous Methylprednisolone for Preventing Stricture after Endoscopic Submucosal Dissection for Esophageal Cancer: A Preliminary Study
Joint Authors
Watanabe, Ko
Nakamura, Jun
Sato, Masaki
Hikichi, Takuto
Ohira, Hiromasa
Obara, Katsutoshi
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
A wide mucosal defect after endoscopic submucosal dissection (ESD) for esophageal cancer is associated with increased risk of stricture.
This study was conducted to evaluate the feasibility of short-period, high-dose intravenous methylprednisolone administration (steroid pulse therapy) in preventing post-ESD esophageal stricture.
Methods.
This prospective study examined 13 lesions in 11 consecutive patients with esophageal squamous cell carcinoma who underwent ESD that involved three-quarters or more of the circumference of the esophagus or who had a longitudinal resected specimen diameter of ≥5 cm.
Steroid pulse therapy was initiated the day after ESD and continued for 3 consecutive days.
The primary endpoint was the stricture rate after ESD.
Secondary endpoints were adverse events (AEs) associated with steroid pulse therapy, time until the development of stricture, and the frequency and duration of endoscopic balloon dilation (EBD).
Results.
The stricture rate was 54.5% (6/11).
The median time until stricture development was 15 days.
The median number of EBD sessions required was 2.5.
The median duration of EBD was 14.5 days.
AEs related to steroid pulse therapy and postprocedure complications were not observed.
Conclusion.
No preventive effect of the stricture after esophageal ESD by steroid pulse therapy was found, although the therapy was administered safely.
American Psychological Association (APA)
Nakamura, Jun& Hikichi, Takuto& Watanabe, Ko& Sato, Masaki& Obara, Katsutoshi& Ohira, Hiromasa. 2017. Feasibility of Short-Period, High-Dose Intravenous Methylprednisolone for Preventing Stricture after Endoscopic Submucosal Dissection for Esophageal Cancer: A Preliminary Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156729
Modern Language Association (MLA)
Nakamura, Jun…[et al.]. Feasibility of Short-Period, High-Dose Intravenous Methylprednisolone for Preventing Stricture after Endoscopic Submucosal Dissection for Esophageal Cancer: A Preliminary Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1156729
American Medical Association (AMA)
Nakamura, Jun& Hikichi, Takuto& Watanabe, Ko& Sato, Masaki& Obara, Katsutoshi& Ohira, Hiromasa. Feasibility of Short-Period, High-Dose Intravenous Methylprednisolone for Preventing Stricture after Endoscopic Submucosal Dissection for Esophageal Cancer: A Preliminary Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1156729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156729