Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39IL-17 and TGFβ1Smad3 Signal Pathways
Joint Authors
Gu, Xiaofeng
Yang, Haojie
Liu, Zhaoheng
Long, Qi
Liu, Haoge
Jiao, Yang
Wang, Wei
Niu, Jie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Fibrotic remodeling has become the result of many lung diseases, and these disorders can be categorized with known as well as unknown etiologies.
Idiopathic pulmonary fibrosis is the most fatal disease among the unknown etiology.
TGFβ1/Smad3 signal pathway plays an important role in lung fibrosis and epithelial regeneration.
This study investigated the effects and mechanism of Feibi Recipe (FBR) on pulmonary fibrosis.
In this experiment, C57BL/6 mice were used and bleomycin was used to induce the lung injury.
Meanwhile, the study showed a significant reduction in pathological response and mediators of inflammation and fibrosis such as IL-6, ICAM-1, IL-13, IL-17, BRP-39, TGFβ1, Smad3, and Smad7 were identified.
Collectively, the FBR appears to attenuate the lung injury and the modeling of fibrosis in mice.
American Psychological Association (APA)
Wang, Wei& Liu, Zhaoheng& Niu, Jie& Yang, Haojie& Long, Qi& Liu, Haoge…[et al.]. 2020. Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39IL-17 and TGFβ1Smad3 Signal Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156733
Modern Language Association (MLA)
Wang, Wei…[et al.]. Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39IL-17 and TGFβ1Smad3 Signal Pathways. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156733
American Medical Association (AMA)
Wang, Wei& Liu, Zhaoheng& Niu, Jie& Yang, Haojie& Long, Qi& Liu, Haoge…[et al.]. Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39IL-17 and TGFβ1Smad3 Signal Pathways. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156733
