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Role of Helicobacter pylori Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura
Joint Authors
Sheema, Khan
Ikramdin, Ujjan
Arshi, Naz
Farah, Naz
Imran, Sheikh
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys native platelets.
In this condition an autoantibody is generated against a platelet antigen.
ITP affects women more often than men and is more common in children than adults.
Objective.
To assess the effect of Helicobacter pylori eradication therapy (HPET) on platelet count in Helicobacter pylori associated chronic immune thrombocytopenic purpura (chronic ITP) in adult.
Materials and Methods.
It is an interventional prospective study conducted at Liaquat University of Medical and Health Sciences, Jamshoro, from 2014 to 2015.
A set of 85 patients diagnosed with chronic ITP were included in the study via convenient sampling.
Patients with platelets count < 100 × 109/L for >3 months were selected.
They were posed to first-line investigations which comprised complete blood count (CBC) and peripheral blood smear examination followed by second-line tests including bone marrow examination and Helicobacter pylori stool specific antigen (HpSA-EIA).
Standard H.
pylori eradication therapy was offered and the patients were assessed at regular intervals for 6 months.
Results.
Of the 85 study patients, 32 (37.6%) were male and 53 (62.3%) were female.
Mean ages of H.
pylori positive and negative subjects were 43.89 ± 7.06 and 44.75 ± 7.91 years, respectively.
Bone marrow examination confirmed the diagnosis and excluded other related BM disorders.
H.
pylori stool antigen (HpSA) was detected in 34 (40%) patients and hence regarded as H.
pylori positive; the rest were negative.
Treatment with eradication therapy significantly improved the mean platelet counts from 48.56±21.7 × 109/l to 94.2±26.8 × 109/l.
Conclusion.
We concluded that the anti-H.
pylori eradication therapy improves blood platelet counts in chronic immune thrombocytopenia.
American Psychological Association (APA)
Sheema, Khan& Ikramdin, Ujjan& Arshi, Naz& Farah, Naz& Imran, Sheikh. 2017. Role of Helicobacter pylori Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1156735
Modern Language Association (MLA)
Sheema, Khan…[et al.]. Role of Helicobacter pylori Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura. Gastroenterology Research and Practice No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1156735
American Medical Association (AMA)
Sheema, Khan& Ikramdin, Ujjan& Arshi, Naz& Farah, Naz& Imran, Sheikh. Role of Helicobacter pylori Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1156735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156735