The Influence of BuqiHuoxueTongluo Formula on Histopathology and Pulmonary Function Test in Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats
Joint Authors
Zhang, Xiaomei
Yu, Xiaolin
Liu, Xuemei
Zhang, Yanxia
Yang, Xiaohua
Wang, Xinxiang
Yan, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
BuqiHuoxueTongluo Formula (BHTF) is an effective herbal prescription based on traditional Chinese medicine for idiopathic pulmonary fibrosis (IPF).
The aim of this study was to elucidate the influence of BHTF on induced IPF model through the aspect of histopathology and pulmonary function test.
Wistar rats with bleomycin-induced IPF were given BHTF via intragastric gavage.
After 14 days and 28 days of treatment, respectively, on these two time points, we first performed pulmonary function test, performed ventilation measure, and traced the Pressure-Volume Loop under anesthesia.
Then, rats were sacrificed for hematoxylin-eosin and Masson’s trichrome staining, immunohistochemistry staining of TGF-β1 and α-SMA, and observation through transmission electron microscope.
BHTF reduced infiltration of inflammation cells, collagen deposition, and fibrosis proliferation in pulmonary mesenchyme, inhibited the expression of TGF-β1 and α-SMA, and avoided the abnormality of ultrastructure and quantities of lamellar bodies.
It also ameliorated the parameters of FVC, MVV, PEF, FEF25, and Cdyn, maintained the shape of the Pressure-Volume Loop, and improved hysteresis.
BHFT relieved the histopathologic changes, improved ventilation function, compliance, and work of breathing, meliorated the capacity and elasticity of the lungs, and stabilized the alveolar surface tension.
Further speaking, it had a potential impact on the secretion of pulmonary surfactant.
American Psychological Association (APA)
Yu, Xiaolin& Zhang, Yanxia& Yang, Xiaohua& Zhang, Xiaomei& Wang, Xinxiang& Liu, Xuemei…[et al.]. 2018. The Influence of BuqiHuoxueTongluo Formula on Histopathology and Pulmonary Function Test in Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156742
Modern Language Association (MLA)
Yu, Xiaolin…[et al.]. The Influence of BuqiHuoxueTongluo Formula on Histopathology and Pulmonary Function Test in Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156742
American Medical Association (AMA)
Yu, Xiaolin& Zhang, Yanxia& Yang, Xiaohua& Zhang, Xiaomei& Wang, Xinxiang& Liu, Xuemei…[et al.]. The Influence of BuqiHuoxueTongluo Formula on Histopathology and Pulmonary Function Test in Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156742