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Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach
Joint Authors
Wang, Yang
Tang, Tao
Li, Pengfei
Zhong, Yuanyuan
Liu, Tao
Cui, Hanjin
Luo, Jiekun
Huang, Zebing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-04
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Objectives.
Xuefu Zhuyu decoction (XFZYD), a traditional Chinese medicine (TCM) formula, has been demonstrated to be effective for the treatment of traumatic brain injury (TBI).
However, the underlying pharmacological mechanisms remain unclear.
This study aims to explore the potential action mechanisms of XFZYD in the treatment of TBI and to elucidate the combination principle of this herbal formula.
Methods.
A network pharmacology approach including ADME (absorption, distribution, metabolism, and excretion) evaluation, target prediction, known therapeutic targets collection, network construction, and molecule docking was used in this study.
Results.
A total of 119 bioactive ingredients from XFZYD were predicted to act on 47 TBI associated specific proteins which intervened in several crucial pathological processes including apoptosis, inflammation, antioxidant, and axon genesis.
Almost each of the bioactive ingredients targeted more than one protein.
The molecular docking simulation showed that 91 pairs of chemical components and candidate targets had strong binding efficiencies.
The “Jun”, “Chen”, and “Zuo-Shi” herbs from XFZYD triggered their specific targets regulation, respectively.
Conclusion.
Our work successfully illuminates the “multicompounds, multitargets” therapeutic action of XFZYD in the treatment of TBI by network pharmacology with molecule docking method.
The present work may provide valuable evidence for further clinical application of XFZYD as therapeutic strategy for TBI treatment.
American Psychological Association (APA)
Zhong, Yuanyuan& Luo, Jiekun& Tang, Tao& Li, Pengfei& Liu, Tao& Cui, Hanjin…[et al.]. 2018. Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1156752
Modern Language Association (MLA)
Zhong, Yuanyuan…[et al.]. Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1156752
American Medical Association (AMA)
Zhong, Yuanyuan& Luo, Jiekun& Tang, Tao& Li, Pengfei& Liu, Tao& Cui, Hanjin…[et al.]. Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1156752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156752