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The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat Model
Joint Authors
Deng, Chunhua
Liu, Guihua
Chen, Haicheng
Xie, Yun
Deng, Cuncan
Zhang, Chi
Lv, Linyan
Yao, Jiahui
Sun, Xiangzhou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Ningmitai (NMT) capsule has been widely prescribed for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), but the mechanism remains unclear.
This study aims to evaluate the therapeutic effects of the NMT capsule in the experimental autoimmune prostatitis (EAP) rat models and explore its possible mechanisms.
Methods.
A total of fifty male Sprague Dawley rats were used in this study.
Prostate extract was obtained for the induction of EAP rat models.
The EAP rats were randomly divided into the model group, NMT low-dose group (0.45 g/kg/d), NMT medium-dose group (0.90 g/kg/d), and NMT high-dose group (1.80 g/kg/d), with six rats per group.
Three NMT treatment groups were administered with the NMT capsule by gavage for 30 days.
HE staining was used for histopathological analyses of prostate tissues.
Western blotting was used to measure the expression of proinflammatory factors IL-1β and TNF-α.
The MDA level was detected to reflect the level of oxidative stress.
The bilateral dorsal root ganglia of T3/L1 to S4 were dissected to measure the substance P expression.
Results.
EAP rat models were successfully constructed, in which extensive infiltration of inflammatory cells was found.
Treatment of NMT capsule for 30 days and the infiltration of inflammatory cells were significantly mitigated (P<0.05), especially in the NMT medium-dose group and NMT high-dose group.
Moreover, the expression of IL-1β and the level of MDA were significantly decreased (P<0.05).
In addition, NMT treatment could significantly alleviate substance P expression in dorsal root ganglia.
Conclusion.
Our findings demonstrate that the NMT capsule can alleviate inflammatory response and oxidative stress and reduce the production of substance P in EAP rats.
This provides a theoretical basis for the clinical application of NMT capsule for CP/CPPS treatment.
American Psychological Association (APA)
Chen, Haicheng& Xie, Yun& Deng, Cuncan& Zhang, Chi& Lv, Linyan& Yao, Jiahui…[et al.]. 2020. The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156755
Modern Language Association (MLA)
Chen, Haicheng…[et al.]. The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1156755
American Medical Association (AMA)
Chen, Haicheng& Xie, Yun& Deng, Cuncan& Zhang, Chi& Lv, Linyan& Yao, Jiahui…[et al.]. The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat Model. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156755