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Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients
Joint Authors
Yang, Haojie
Li, Ying
Wu, Jiong
Wang, Zhenyi
Gan, Dan
Jin, Lei
Qin, Kaijian
Cui, Can
Wang, Xiao-Su
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and the rectum.
Recently, some studies have shown that microorganisms in the gut play important roles in many chronic diseases such as UC.
Methods.
To study the candidate viruses and bacteria involved in UC and to investigate the therapeutic mechanism of Quyushengxin formula (QYSX) in UC patients, metagenomic sequencing was performed on the feces from healthy donors and UC patients before and after QYSX treatment.
Results.
QYSX improved the symptoms of UC.
In all participants, Caudovirales and Herpesvirales were the most dominant viruses.
The abundance of Caudovirales in UC patients was significantly higher than that in the normal controls, while QYSX restored Caudovirales abundance.
Furthermore, the abundance of crAssphage was enhanced in UC patients compared with the normal control, while the diversity was then decreased after QYSX treatment.
However, there was no significant difference (P>0.05).
Additionally, other non-crAssphage bacteriophages including phiST, SP-10, and phi17:2 were higher in UC patients and QYSX decreased these viruses, while the trends of MED4−213, P-HM1, and P−HM2 were adverse.
Interestingly, PhiDP23.1 was only found in UC patients before and after QYSX treatment.
In addition, Bifidobacterium, Bacteroidetes, Prevotellaceae, Actinobacteria, and Corynebacteriales were the biomarkers in UC patients after QYSX treatment due to their high abundance.
GO terms and KEGG analysis showed that the identified gut microbiome was involved in many biological processes and pathways.
Conclusions.
QYSX could regulate disordered gut microbiome and phages, indicating that QYSX has great therapeutic potential for UC.
American Psychological Association (APA)
Yang, Haojie& Gan, Dan& Li, Ying& Wang, Xiao-Su& Jin, Lei& Qin, Kaijian…[et al.]. 2020. Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156756
Modern Language Association (MLA)
Yang, Haojie…[et al.]. Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156756
American Medical Association (AMA)
Yang, Haojie& Gan, Dan& Li, Ying& Wang, Xiao-Su& Jin, Lei& Qin, Kaijian…[et al.]. Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156756