In Vitro and In Vivo Inhibitory Effect of Gujin Xiaoliu Tang in Non-Small Cell Lung Cancer
Joint Authors
Zhou, Dai-Han
Dai, Xiaojun
Hou, Chao
Wu, Yong-Jian
Wang, Qing-Ying
Wu, Yin-Qiu
Zhang, En-Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Non-small cell lung cancer (NSCLC) is a serious threat to people’s health.
This study aims to determine the possible effect of Gujin Xiaoliu Tang (GJXLT) on NSCLC, which is an empirical formula from Professor Dai-Han Zhou.
In this study, chromatographic fingerprinting of GJXLT and A549 cell model in vitro and in vivo was established.
We cultured A549 cells in vitro and found that GJXLT inhibited A549 cell growth and induced apoptosis.
Compared with the control group, the expression of p-STAT3 and VEGF proteins in the GJXLT groups was decreased.
Similar findings were also observed in vivo.
First, GJXLT inhibited the growth of transplanted tumor and did not reduce the weight of the tumor-bearing mice in comparison with that of the control group.
Then, the Ki-67 expression of transplanted tumor in the GJXLT groups was decreased.
In addition, the apoptosis rate of transplanted tumor in the GJXLT groups was increased.
Overall, our data showed that GJXLT inhibited A549 cell proliferation and induced apoptosis in vivo and in vitro.
Furthermore, GJXLT inhibited the growth of lung cancer xenograft in nude mice model with no obvious side effects.
The anti-tumor effect of GJXLT might also be related to the inhibition of p-STATS and VEGF expression in the JAK2/STAT3 pathway.
Our results demonstrated the potential of GJXLT as a novel treatment for NSCLC.
American Psychological Association (APA)
Hou, Chao& Zhou, Dai-Han& Wu, Yong-Jian& Dai, Xiaojun& Wang, Qing-Ying& Wu, Yin-Qiu…[et al.]. 2018. In Vitro and In Vivo Inhibitory Effect of Gujin Xiaoliu Tang in Non-Small Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156762
Modern Language Association (MLA)
Hou, Chao…[et al.]. In Vitro and In Vivo Inhibitory Effect of Gujin Xiaoliu Tang in Non-Small Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156762
American Medical Association (AMA)
Hou, Chao& Zhou, Dai-Han& Wu, Yong-Jian& Dai, Xiaojun& Wang, Qing-Ying& Wu, Yin-Qiu…[et al.]. In Vitro and In Vivo Inhibitory Effect of Gujin Xiaoliu Tang in Non-Small Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156762